Diffey B L, Langtry J
Department of Medical Physics, Dryburn Hospital, Durham, United Kingdom.
Arch Dermatol. 1989 Oct;125(10):1355-8.
Monochromator phototesting has been carried out in 22 subjects before and 2 weeks after therapy with either bendroflumethiazide (bendrofluazide) or hydrochlorothiazide. An increase in erythemal sensitivity was observed in several subjects in those wave bands that are maximally absorbed by the respective drugs in vitro. Both drugs showed similar phototoxic capabilities, yet in clinical practice, reports of photosensitivity caused by hydrochlorothiazide are much more common than those caused by bendroflumethiazide. One possible reason is suggested.
在22名受试者中，于使用苄氟噻嗪（bendrofluazide）或氢氯噻嗪治疗前及治疗后2周进行了单色仪光测试。在体外被相应药物最大程度吸收的那些波段中，观察到数名受试者的红斑敏感性增加。两种药物显示出相似的光毒性，但在临床实践中，氢氯噻嗪引起的光敏性报告比苄氟噻嗪引起的更为常见。文中提出了一个可能的原因。
