Enhanced AMD detection in OCT images using GLCM texture features with Machine Learning and CNN methods.

Global blindness is substantially influenced by age-related macular degeneration (AMD). It significantly shortens people's lives and severely impairs their visual acuity. AMD is becoming more common, requiring improved diagnostic and prognostic methods. Treatment efficacy and patient survival rates stand to benefit greatly from these upgrades. To improve AMD diagnosis in preprocessed retinal images, this study uses Grey Level Co-occurrence Matrix (GLCM) features for texture analysis. The selected GLCM features include contrast and dissimilarity. Notably, grayscale pixel values were also integrated into the analysis. Key factors such as contrast, correlation, energy, and homogeneity were identified as the primary focuses of the study. Various supervised machine learning (ML) and CNN techniques were employed on Optical Coherence Tomography (OCT) image datasets. The impact of feature selection on model performance is evaluated by comparing all GLCM features, selected GLCM features, and grayscale pixel features. Models using GSF features showed low accuracy, with OCTID at 23% and Kermany at 54% for BC, and 23% and 53% for CNN. In contrast, GLCM features achieved 98% for OCTID and 73% for Kermany in RF, and 83% and 77% in CNN. SFGLCM features performed the best, achieving 98% for OCTID across both RF and CNN, and 77% for Kermany. Overall, SFGLCM and GLCM features outperformed GSF, improving accuracy, generalization, and reducing overfitting for AMD detection. The Python-based research demonstrates ML's potential in ophthalmology to enhance patient outcomes.