一例因急性髓系白血病结肠定位导致的致命性腹膜炎病例。
A fatal case of peritonitis due to colonic localization of acute myeloid leukemia.
作者信息
Buzzatti Elisa, Botti Caterina, Presicci Roberta, Mauro Cristina, Blasi Francesca, Paterno Giovangiacinto, Savino Luca, Palmieri Raffaele, Gurnari Carmelo, Ottone Tiziana, Mallegni Flavia, Meddi Elisa, Moretti Federico, Tiravanti Ilaria, Cardillo Lucia, Mezzanotte Valeria, Taka Kristian, De Marchi Lucrezia, Venditti Adriano, Villa Massimo, Del Principe Maria Ilaria
机构信息
Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.
Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
出版信息
Ann Hematol. 2025 Jan;104(1):847-853. doi: 10.1007/s00277-024-06172-2. Epub 2025 Jan 7.
Myeloid sarcoma (MS) is an extramedullary localization of immature granulocyte cells that can occur in association with acute myeloid leukemia (AML). Gastrointestinal involvement is relatively common in MS, but exclusive colonic localization is a rare occurrence. Here, we report on a 53-year-old male patient affected by AML developing a severe abdominal pain caused by intestinal perforation requiring surgical intervention. The post-mortem examination revealed an infiltrate consistent with MS. Diagnosis of colonic MS can be difficult due to non-specific symptoms and complicated by the challenges associated with exploring this area. Clinical acumen is crucial to promptly establish adequate management due to the potentially life-threatening nature of this condition.
髓系肉瘤（MS）是未成熟粒细胞的髓外定位，可与急性髓系白血病（AML）相关发生。胃肠道受累在MS中相对常见，但单纯结肠定位则很少见。在此，我们报告一名53岁男性AML患者，因肠穿孔导致严重腹痛，需要手术干预。尸检显示浸润符合MS。由于症状不具特异性且探索该区域存在挑战，结肠MS的诊断可能困难。鉴于这种情况可能危及生命，临床敏锐度对于迅速确立适当的治疗至关重要。
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