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Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution.

作者信息

Ma Haoran, Srivastava Supriya, Ho Shamaine Wei Ting, Xu Chang, Lian Benedict Shi Xiang, Ong Xuewen, Tay Su Ting, Sheng Taotao, Lum Huey Yew Jeffrey, Abdul Ghani Siti Aishah Binte, Chu Yunqiang, Huang Kie Kyon, Goh Yeek Teck, Lee Minghui, Hagihara Takeshi, Ng Clara Shi Ya, Tan Angie Lay Keng, Zhang Yanrong, Ding Zichen, Zhu Feng, Ng Michelle Shu Wen, Joseph Craig Ryan Cecil, Chen Hui, Li Zhen, Zhao Joseph J, Rha Sun Young, Teh Ming, Yeong Joe, Yong Wei Peng, So Jimmy Bok-Yan, Sundar Raghav, Tan Patrick

机构信息

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

出版信息

Cancer Discov. 2025 Apr 2;15(4):767-792. doi: 10.1158/2159-8290.CD-24-0605.

DOI:10.1158/2159-8290.CD-24-0605
PMID:39774838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11962405/
Abstract

Integration of spatial transcriptomic (GeoMx Digital Spatial Profiler) and single-cell RNA sequencing data from multiple gastric cancers identifies spatially resolved expression-based intratumoral heterogeneity, associated with distinct immune microenvironments. We uncovered two separate evolutionary trajectories associated with specific molecular subtypes, clinical prognoses, stromal neighborhoods, and genetic drivers. Tumor-stroma interfaces emerged as a unique state of tumor ecology.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/3fdf9fee8e91/cd-24-0605fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/62ce0e16c272/cd-24-0605fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/527da0277912/cd-24-0605fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/b6e990f28dd2/cd-24-0605fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/159e2c28239b/cd-24-0605fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/8f433c37d9b0/cd-24-0605fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/5ac492488081/cd-24-0605fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/3fdf9fee8e91/cd-24-0605fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/62ce0e16c272/cd-24-0605fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/527da0277912/cd-24-0605fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/b6e990f28dd2/cd-24-0605fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/159e2c28239b/cd-24-0605fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/8f433c37d9b0/cd-24-0605fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/5ac492488081/cd-24-0605fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/563c/11962405/3fdf9fee8e91/cd-24-0605fig7.jpg

相似文献

[1]
Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution.

Cancer Discov. 2025-4-2

[2]
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[3]
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[4]
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[5]
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[6]
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Int J Mol Sci. 2023-7-12

[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Single-cell transcriptomic analysis reveals metastatic and immunosuppressive characteristics in meningioma brain-tumor interface.

J Transl Med. 2025-8-18

[2]
OncoTrace-TOO: Interpretable Machine Learning Framework for Cancer Tissue-of-Origin Identification Using Transcriptomic Signatures.

Cancer Rep (Hoboken). 2025-8

[3]
Applications and advances of multi-omics technologies in gastrointestinal tumors.

Front Med (Lausanne). 2025-7-23

[4]
Harnessing technologies to unravel gastric cancer heterogeneity.

Trends Cancer. 2025-8

[5]
Cancer associated fibroblasts in cancer development and therapy.

J Hematol Oncol. 2025-3-28

[6]
Spatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer.

Gastric Cancer. 2025-5

本文引用的文献

[1]
Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases.

Gastroenterology. 2024-12

[2]
Embracing cancer complexity: Hallmarks of systemic disease.

Cell. 2024-3-28

[3]
SAW: an efficient and accurate data analysis workflow for Stereo-seq spatial transcriptomics.

GigaByte. 2024-2-20

[4]
Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples.

Nat Protoc. 2024-6

[5]
Potential crosstalk between SPP1 + TAMs and CD8 + exhausted T cells promotes an immunosuppressive environment in gastric metastatic cancer.

J Transl Med. 2024-2-16

[6]
Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Colon Cancer from Primary Tumor and Liver Metastasis.

Life (Basel). 2024-1-15

[7]
Current status and prospects of GREM1 research in cancer (Review).

Mol Clin Oncol. 2023-7-19

[8]
Non-cell-autonomous cancer progression from chromosomal instability.

Nature. 2023-8

[9]
Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response.

Nat Commun. 2023-8-18

[10]
Cancer-associated fibroblast classification in single-cell and spatial proteomics data.

Nat Commun. 2023-7-18

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