Farmer Aaron, Anderson Kathryn B, Buddhari Darunee, Hortiwakul Thanaporn, Charernmak Boonsri, Thaisomboonsuk Butsaya, Wongstitwilairoong Tippa, Hunsawong Taweewun, Klungthong Chonticha, Chinnawirotpisan Piyawan, Chusri Sarunyou, Fernandez Stefan
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
SUNY Upstate Medical University, Syracuse, New York, United States of America.
PLoS Negl Trop Dis. 2025 Jan 7;19(1):e0012776. doi: 10.1371/journal.pntd.0012776. eCollection 2025 Jan.
Chikungunya virus (CHIKV) infections are distributed across the globe, causing significant and, often, lasting morbidity. CHIKV vaccines are in development, but their evaluation is limited by the unpredictability of CHIKV transmission, which classically manifests as explosive epidemics separated by variable interepidemic periods. A passive surveillance study for undifferentiated febrile illness was established in southern Thailand in 2012 and is ongoing. Among 1466 febrile individuals with acute and convalescent specimens, 398 (27.1%) had molecular or serological evidence of acute CHIKV infection. The proportions of participants confirmed to have CHIKV infection differed by year, being highest during epidemic periods (41.1% in 2018-2019, corresponding to a large regional CHIKV outbreak, compared to 19.3% in 2012-2017). These data suggest persistent circulation of CHIKV in the study area, though additional studies are needed to confirm these findings and to discern whether this persistence reflects widespread, low-level transmission or migrating bursts of focal epidemic activity.
基孔肯雅病毒（CHIKV）感染遍布全球，会导致严重且往往持久的发病情况。CHIKV疫苗正在研发中，但其评估受到CHIKV传播不可预测性的限制，这种传播通常表现为爆发性疫情，且疫情间隔期长短不一。2012年在泰国南部开展了一项针对未分化发热性疾病的被动监测研究，该研究仍在进行中。在1466名采集了急性期和恢复期标本的发热个体中，398人（27.1%）有急性CHIKV感染的分子学或血清学证据。确诊感染CHIKV的参与者比例因年份而异，在流行期间最高（2018 - 2019年为41.1%，对应一次大规模的区域性CHIKV疫情，而2012 - 2017年为19.3%）。这些数据表明CHIKV在研究区域持续传播，不过还需要更多研究来证实这些发现，并确定这种持续性是反映了广泛的低水平传播还是局部疫情活动的迁移性爆发。
