Roos R P, Davis K, Meltzer H Y
Arch Gen Psychiatry. 1985 Feb;42(2):124-8. doi: 10.1001/archpsyc.1985.01790250018002.
Autoimmune processes and viral infections have been proposed as causative factors in psychiatric diseases. To investigate this issue, we screened serum and CSF from schizophrenic and depressed patients for quantitative and qualitative immunoglobulin abnormalities. Qualitative immunoglobulin abnormalities were assessed by isoelectric focusing (IEF) since the presence of IEF oligoclonal immunoglobulin bands is a feature of viral and autoimmune diseases. We found no significant elevation of immunoglobulin levels or increased incidence of oligoclonal immunoglobulin bands, suggesting that viruses and autoimmunity are not involved in the major psychoses.
自身免疫过程和病毒感染已被提出作为精神疾病的致病因素。为了研究这个问题，我们对精神分裂症患者和抑郁症患者的血清和脑脊液进行了筛查，以寻找定量和定性的免疫球蛋白异常情况。通过等电聚焦（IEF）评估定性免疫球蛋白异常情况，因为IEF寡克隆免疫球蛋白条带的存在是病毒和自身免疫性疾病的一个特征。我们发现免疫球蛋白水平没有显著升高，寡克隆免疫球蛋白条带的发生率也没有增加，这表明病毒和自身免疫与主要精神病无关。
