Zimmerman M, Coryell W, Pfohl B M
Arch Gen Psychiatry. 1985 Mar;42(3):300-4. doi: 10.1001/archpsyc.1985.01790260098012.
A sample of 184 hospitalized primary unipolar depressives was used to examine the relationship between the dexamethasone suppression test (DST) and Winokur's familial typology as a function of the broadness of the criteria used to diagnose the patients' first-degree relatives. When a high threshold was used (ie, alcoholic relatives were treated, antisocial relatives had legal problems, and depressed relatives were hospitalized), the DST-familial subtype relationship was much stronger than when a low threshold was used (ie, relatives were diagnosed according to the Family History Research Diagnostic Criteria). The differences in diagnosing family members may be responsible for the inconsistent results reported by investigators examining the relationship between Winokur's typology and the DST.
选取184例住院的原发性单相抑郁症患者样本，以研究地塞米松抑制试验（DST）与维诺克家族类型学之间的关系，该关系是用于诊断患者一级亲属的标准宽泛程度的函数。当采用高阈值时（即酗酒亲属接受治疗、反社会亲属有法律问题、抑郁亲属住院），DST与家族亚型之间的关系比采用低阈值时（即根据家族史研究诊断标准诊断亲属）要强得多。诊断家庭成员的差异可能是研究维诺克类型学与DST之间关系的研究者所报告结果不一致的原因。
