Zimmerman M, Coryell W, Pfohl B, Stangl D
University of Iowa, Department of Psychiatry, Iowa City 52242.
Eur Arch Psychiatry Neurol Sci. 1988;237(3):166-70. doi: 10.1007/BF00451285.
We examined the prognostic validity of Winokur's familial subtypes of depression in 184 in-patients with primary unipolar major depression. Patients with familial pure depressive disease had a more favorable hospital course and reported less symptoms during a 6-month follow-up evaluation than patients with depressive spectrum disease or sporadic depressive disease. Consistent with previous studies of the validity of the familial subtypes, the use of stringent thresholds to diagnose the patient's relatives increased the validity of classification.
我们对184例原发性单相重度抑郁症住院患者中Winokur抑郁症家族亚型的预后有效性进行了研究。与抑郁谱系疾病或散发性抑郁疾病患者相比，家族性单纯抑郁疾病患者在6个月的随访评估中病程更有利，症状报告更少。与先前关于家族亚型有效性的研究一致，使用严格阈值诊断患者亲属提高了分类的有效性。
