Carbone Ludovico, Incognito Giosuè Giordano, Incognito Dalila, Nibid Lorenzo, Caruso Giuseppe, Berretta Massimiliano, Taffon Chiara, Palumbo Marco, Perrone Giuseppe, Roviello Franco, Marrelli Daniele
Unit of Surgical Oncology, Department of Medicine Surgery and Neuroscience, University of Siena, Viale Mario Bracci 16, 53100, Siena, Italy.
Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123, Catania, Italy.
Clin Transl Oncol. 2025 Jan 8. doi: 10.1007/s12094-024-03837-2.
Epithelial-to-mesenchymal transition (EMT) is a biological process by which epithelial cells increase their motility and acquire invasive capacity. It represents a crucial driver of cancer metastasis and peritoneal dissemination. EMT plasticity, with cells exhibiting hybrid epithelial/mesenchymal states, and its reverse process, mesenchymal-to-epithelial transition (MET), allows them to adapt to different microenvironments and evade therapeutic intervention. Resistance to conventional treatments, including chemotherapy, is a major problem. Therapies targeting EMT may inhibit tumour cell migration and invasion, while affecting normal cells and repair mechanisms, resulting in potential side effects. This paper addresses the question of the impact of EMT status on cancers with potential spread to the peritoneum, which has remained unclear in literature. Relevant studies were selected from 2000 to 2024. Three macrosections were analysed: (i) pathological characteristics, (ii) surgical implications and (iii) oncological therapies. The focus was on survival and peritoneal recurrence time in patients who underwent surgical treatment.
上皮-间质转化（EMT）是一个生物学过程，通过该过程上皮细胞增加其运动能力并获得侵袭能力。它是癌症转移和腹膜播散的关键驱动因素。EMT可塑性使细胞呈现混合上皮/间质状态，其逆向过程即间质-上皮转化（MET），使它们能够适应不同的微环境并逃避治疗干预。对包括化疗在内的传统治疗产生耐药性是一个主要问题。针对EMT的疗法可能会抑制肿瘤细胞的迁移和侵袭，但同时会影响正常细胞和修复机制，从而导致潜在的副作用。本文探讨了EMT状态对可能扩散至腹膜的癌症的影响问题，而这一问题在文献中仍不明确。从2000年至2024年选取了相关研究。分析了三个主要方面：（i）病理特征，（ii）手术意义，以及（iii）肿瘤治疗。重点关注接受手术治疗患者的生存率和腹膜复发时间。
