Isola Gaetano, Polizzi Alessandro, Serra Sara, Boato Mattia, Sculean Anton
Department of General Surgery and Medical-Surgical Specialities, Unit of Periodontology, University of Catania, Catania, Italy.
Department of Periodontology, University of Bern, Bern, Switzerland.
Periodontol 2000. 2025 Jan 8. doi: 10.1111/prd.12621.
To provide a comprehensive and updated mapping of observational studies assessing the relationship between periodontitis and systemic diseases through a bibliometric and visual analysis. A search was conducted using the Web of Science database, covering the period 1989 to 2024. The Medical Subject Headings (MeSH) from the US National Library of Medicine was used to categorize systemic conditions, focusing on terms unrelated to stomatognathic diseases. The analysis included keyword co-occurrence mapping, co-authorship, bibliographic coupling, and co-citation analysis. Quality indicators such as silhouette score, modularity, and centrality were considered to assess the network's quality. The research strategy identified 6106 records, of which 1519 met the inclusion criteria. The analysis revealed that 46.73% of the literature on the topic was published in the last 5 years and that the annual publication trend peaked in 2023. Nutritional & Metabolic Diseases (n = 398), Cardiovascular Diseases (n = 335), Female Urogenital Diseases & Pregnancy Complications (n = 244), and Musculoskeletal Diseases (n = 182) were the most representative categories of systemic diseases associated with periodontitis. The most co-cited journals on the topic were the Journal of Periodontology (n = 1412), the Journal of Clinical Periodontology (n = 1343), the Journal of Dental Research (n = 940), and Periodontology 2000 (n = 849). The USA, China, Brazil, and Sweden were the countries that contributed the most to the number of publications. The analysis conducted in the present study revealed a growing trend of observational studies evaluating the association between periodontitis and systemic diseases, highlighting the negative impact of periodontitis on a plethora of systemic conditions and a rising translational interest in this relationship. With an aging population, periodontitis is expected to affect a growing number of people in the coming decades, presenting significant challenges to public health. Improved knowledge is, therefore, essential to enable more comprehensive care, preventive strategies, and optimal oral health for patients with periodontitis.
通过文献计量学和可视化分析，提供一份全面且最新的关于评估牙周炎与全身疾病之间关系的观察性研究图谱。使用科学网数据库进行检索，涵盖1989年至2024年期间。美国国立医学图书馆的医学主题词表（MeSH）用于对全身疾病进行分类，重点关注与口腔颌面部疾病无关的术语。分析包括关键词共现图谱、共同作者、文献耦合和共被引分析。考虑了诸如轮廓系数、模块度和中心性等质量指标来评估网络质量。研究策略确定了6106条记录，其中1519条符合纳入标准。分析显示，该主题46.73%的文献是在过去5年发表的，且年度发表趋势在2023年达到峰值。营养与代谢疾病（n = 398）、心血管疾病（n = 335）、女性泌尿生殖系统疾病与妊娠并发症（n = 244）以及肌肉骨骼疾病（n = 182）是与牙周炎相关的最具代表性的全身疾病类别。该主题被共引次数最多的期刊是《牙周病学杂志》（n = 1412）、《临床牙周病学杂志》（n = 1343）、《牙科研究杂志》（n = 940）和《牙周病学2000》（n = 849）。美国、中国、巴西和瑞典是发表文章数量贡献最大的国家。本研究进行的分析揭示了评估牙周炎与全身疾病之间关联的观察性研究呈增长趋势，突出了牙周炎对多种全身疾病的负面影响以及对这种关系日益增长的转化研究兴趣。随着人口老龄化，预计在未来几十年牙周炎将影响越来越多的人，给公共卫生带来重大挑战。因此，增进了解对于为牙周炎患者提供更全面的护理、预防策略和最佳口腔健康至关重要。
