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解读肠道-睡眠关系:肠道微生物群与睡眠障碍的文献计量学图谱

Decoding the gut-sleep Nexus: a bibliometric mapping of gut microbiota and sleep disorders.

作者信息

Xu Dingwen, Lu Zihua, Li Qin, Cheng Yuchen, Yang Zhe

机构信息

Department of Clinic, School of Medicine, Yangzhou Polytechnic College, Yangzhou, China.

Department of Orthopaedics, Shanxi Provincial People's Hospital, Taiyuan, China.

出版信息

Front Microbiol. 2025 Jun 2;16:1598173. doi: 10.3389/fmicb.2025.1598173. eCollection 2025.


DOI:10.3389/fmicb.2025.1598173
PMID:40529581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12171216/
Abstract

BACKGROUND: An increasing number of studies have focused on the interaction between gut microbiota and sleep disorders. However, there is currently no bibliometric analysis of the literature on gut microbiota and sleep disorders. This study employs bibliometric methods to analyze the current research status and hotspots in the field of gut microbiota and sleep disorders, providing a reference for future research in this area. METHODS: Articles related to gut microbiota and sleep disorders were retrieved from the WOS core database, covering the period from the database's inception to December 31, 2024. After rigorous screening, VOSviewer and CiteSpace were used to conduct analyses on quantity, collaboration networks, clustering, and citation bursts. RESULTS: The number of articles on gut microbiota and sleep disorders has increased annually, with a significant surge after 2022. China has the highest number of publications, while the United States has the highest citation count. The institution with the most publications is Shanghai Jiao Tong University, and the institution with the most citations is Deakin University. The top 10 journals by publication volume are all ranked above Q2 in the JCR. The most cited article is "Gut microbiome diversity is associated with sleep physiology in humans" by Smith et al., published in PLOS ONE in 2019. The top 10 most frequent keywords are gut microbiota, sleep, depression, inflammation, chain fatty acids, anxiety, brain, oxidative stress, obesity, and health. The keyword cluster "obstructive sleep apnea" is a focal research direction, while fecal microbiota transplantation is a current research hotspot. CONCLUSION: This study reveals the publication trends, collaboration relationships among countries, regions, and authors, and recent research hotspots in the field of gut microbiota and sleep disorders through bibliometric methods, providing an objective data reference for scientific research in this domain.

摘要

背景:越来越多的研究聚焦于肠道微生物群与睡眠障碍之间的相互作用。然而,目前尚无关于肠道微生物群与睡眠障碍文献的文献计量分析。本研究采用文献计量方法分析肠道微生物群与睡眠障碍领域的当前研究现状和热点,为该领域未来的研究提供参考。 方法:从WOS核心数据库中检索与肠道微生物群和睡眠障碍相关的文章,涵盖从数据库建立到2024年12月31日的时间段。经过严格筛选后,使用VOSviewer和CiteSpace对数量、合作网络、聚类和引文爆发进行分析。 结果:关于肠道微生物群和睡眠障碍的文章数量逐年增加,2022年后有显著增长。中国的出版物数量最多,而美国的被引频次最高。发表文章最多的机构是上海交通大学,被引频次最高的机构是迪肯大学。发表量排名前10的期刊在JCR中均排名在Q2以上。被引次数最多的文章是Smith等人于2019年发表在《公共科学图书馆·综合》上的“肠道微生物群多样性与人类睡眠生理学相关”。出现频率最高的前10个关键词是肠道微生物群、睡眠、抑郁、炎症、链脂肪酸、焦虑、大脑、氧化应激、肥胖和健康。关键词聚类“阻塞性睡眠呼吸暂停”是一个重点研究方向,而粪便微生物群移植是当前的研究热点。 结论:本研究通过文献计量方法揭示了肠道微生物群与睡眠障碍领域的发表趋势、国家、地区和作者之间的合作关系以及近期研究热点,为该领域的科学研究提供了客观的数据参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/abecf3da0998/fmicb-16-1598173-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/37a8902f3ffb/fmicb-16-1598173-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/84973d910453/fmicb-16-1598173-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/12713a175b6c/fmicb-16-1598173-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/b0829e1767aa/fmicb-16-1598173-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/9506ec8b2729/fmicb-16-1598173-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/efb69255a7dd/fmicb-16-1598173-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/810a66dd79c0/fmicb-16-1598173-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/abecf3da0998/fmicb-16-1598173-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/37a8902f3ffb/fmicb-16-1598173-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/84973d910453/fmicb-16-1598173-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/12713a175b6c/fmicb-16-1598173-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/b0829e1767aa/fmicb-16-1598173-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/9506ec8b2729/fmicb-16-1598173-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/efb69255a7dd/fmicb-16-1598173-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/810a66dd79c0/fmicb-16-1598173-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5e0/12171216/abecf3da0998/fmicb-16-1598173-g008.jpg

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本文引用的文献

[1]
Gut microbiota and derived metabolites mediate obstructive sleep apnea induced atherosclerosis.

Gut Microbes. 2025-12

[2]
Relationship between periodontitis and systemic diseases: A bibliometric and visual study.

Periodontol 2000. 2025-1-8

[3]
A bibliometric and visual analysis of Parkinson's disease sleep disorders: articles from 2008 to 2023.

Front Psychiatry. 2024-10-17

[4]
Obstructive sleep apnea and obesity: A review of epidemiology, pathophysiology and the effect of weight-loss treatments.

Sleep Med Rev. 2024-12

[5]
Association of lifestyle with sleep health in general population in China: a cross-sectional study.

Transl Psychiatry. 2024-8-4

[6]
Far-Infrared Therapy Based on Graphene Ameliorates High-Fat Diet-Induced Anxiety-Like Behavior in Obese Mice via Alleviating Intestinal Barrier Damage and Neuroinflammation.

Neurochem Res. 2024-7

[7]
Bibliometric Analysis of Brain Stimulation Technologies in Sleep Disorders.

Med Sci Monit. 2024-3-5

[8]
Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder.

Front Immunol. 2024

[9]
Serum C-reactive protein level and sleep characteristics in obstructive sleep apnea syndrome comorbid with panic disorder: a preliminary study.

BMC Psychiatry. 2023-11-20

[10]
Mapping Research Trends and Hotspots in the Link between Alzheimer's Disease and Gut Microbes over the Past Decade: A Bibliometric Analysis.

Nutrients. 2023-7-19

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