• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

意外接触沙林:视觉影响。

Accidental exposure to sarin: vision effects.

作者信息

Rengstorff R H

出版信息

Arch Toxicol. 1985 Jan;56(3):201-3. doi: 10.1007/BF00333427.

DOI:10.1007/BF00333427
PMID:3977601
Abstract

Two men were accidentally exposed to vapors of sarin, a cholinesterase inhibitor and extremely toxic nerve gas. Diagnosis was confirmed by depressed cholinesterase activity, and fixed extremely miotic pupils. No other signs or symptoms developed and neither man required treatment. Recovery to normal cholinesterase activity was gradual over a 90-day period. Pupillary reflexes were not detectable until 11 days after exposure; the miotic pupils dilated slowly over a 30-45 day-period. Eye pain and blurred vision did not occur; visual acuity and amplitude of accommodation were improved for several weeks. Other functions not affected significantly were intraocular pressure, visual fields, color vision, heterophorias, and vergences.

摘要

两名男子意外接触了沙林毒气(一种胆碱酯酶抑制剂和剧毒神经毒气)的蒸气。胆碱酯酶活性降低以及固定的极度缩瞳证实了诊断。未出现其他体征或症状,两人均无需治疗。胆碱酯酶活性在90天内逐渐恢复正常。暴露后11天内未检测到瞳孔反射;缩瞳在30至45天内缓慢扩大。未出现眼痛和视力模糊;视力和调节幅度在数周内有所改善。其他未受明显影响的功能包括眼压、视野、色觉、隐斜视和融合。

相似文献

1
Accidental exposure to sarin: vision effects.意外接触沙林:视觉影响。
Arch Toxicol. 1985 Jan;56(3):201-3. doi: 10.1007/BF00333427.
2
Vision and ocular changes following accidental exposure to organophosphates.意外接触有机磷酸酯后的视力和眼部变化。
J Appl Toxicol. 1994 Mar-Apr;14(2):115-8. doi: 10.1002/jat.2550140213.
3
Sarin poisoning on Tokyo subway.东京地铁沙林毒气中毒事件。
South Med J. 1997 Jun;90(6):587-93. doi: 10.1097/00007611-199706000-00002.
4
[Status of the organ of vision after chronic occupational exposure to lead].
Oftalmol Zh. 1988(2):95-7.
5
Ocular signs and symptoms caused by exposure to sarin gas.接触沙林毒气引起的眼部体征和症状。
Am J Ophthalmol. 1996 Feb;121(2):209-10. doi: 10.1016/s0002-9394(14)70587-2.
6
The Clonidine side effect in the human eye.
Ann Ophthalmol. 1974 Jul;6(7):699-709.
7
Miotic drugs: a review of ocular, visual, and systemic complications.缩瞳药物:眼部、视觉及全身并发症综述
Am J Optom Physiol Opt. 1976 Feb;53(2):70-80.
8
Adverse ocular effects of flecainide.氟卡尼的眼部不良反应。
Acta Ophthalmol Scand. 2001 Apr;79(2):175-6. doi: 10.1034/j.1600-0420.2001.079002175.x.
9
Ocular digitalis effects in normal subjects.正常受试者的眼部洋地黄效应。
Lens Eye Toxic Res. 1990;7(3-4):281-303.
10
Drug toxicity and visual fields.
J Am Optom Assoc. 1980 Sep;51(9):859-62.

引用本文的文献

1
Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review.沙林(GB,O-异丙基甲基磷酰氟)神经毒性:批判性综述。
Crit Rev Toxicol. 2016 Nov;46(10):845-875. doi: 10.1080/10408444.2016.1220916. Epub 2016 Oct 5.
2
Audiological assessment in organophosphorus compound poisoning.有机磷化合物中毒的听力学评估。
Indian J Otolaryngol Head Neck Surg. 2014 Jan;66(1):22-5. doi: 10.1007/s12070-012-0547-0. Epub 2012 Mar 21.
3
Efficacy assessment of a combined anticholinergic and oxime treatment against topical sarin-induced miosis and visual impairment in rats.

本文引用的文献

1
Myopia induced by ocular instillation of physostigmine.通过眼内滴注毒扁豆碱诱发近视。
Am J Optom Arch Am Acad Optom. 1970 Mar;47(3):221-7. doi: 10.1097/00006324-197003000-00005.
2
Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates.
Clin Toxicol. 1974;7(1):1-17. doi: 10.3109/15563657408987971.
3
Cyclopentolate in treatment of sarin miosis.环喷托酯治疗沙林所致瞳孔缩小
Br J Pharmacol. 1973 Jun;48(2):309-13. doi: 10.1111/j.1476-5381.1973.tb06917.x.
抗胆碱能药物与肟联合治疗对局部应用沙林诱导大鼠瞳孔缩小和视力损害的疗效评估
Br J Pharmacol. 2014 May;171(9):2364-74. doi: 10.1111/bph.12586.
4
Advances in toxicology and medical treatment of chemical warfare nerve agents.毒理学和化学战剂医学治疗的进展。
Daru. 2012 Nov 28;20(1):81. doi: 10.1186/2008-2231-20-81.
5
Effects of sarin on the nervous system in rescue team staff members and police officers 3 years after the Tokyo subway sarin attack.东京地铁沙林毒气袭击事件三年后,沙林对救援队工作人员和警察神经系统的影响。
Environ Health Perspect. 2001 Nov;109(11):1169-73. doi: 10.1289/ehp.011091169.
6
Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection.有机磷化学战剂GA、GB和VX的毒性:对公众防护的意义。
Environ Health Perspect. 1994 Jan;102(1):18-38. doi: 10.1289/ehp.9410218.
7
Sarin poisoning of a rescue team in the Matsumoto sarin incident in Japan.日本松本沙林事件中一支救援队遭遇沙林中毒。
Occup Environ Med. 1997 Oct;54(10):697-701. doi: 10.1136/oem.54.10.697.
4
Miotic drugs: a review of ocular, visual, and systemic complications.缩瞳药物:眼部、视觉及全身并发症综述
Am J Optom Physiol Opt. 1976 Feb;53(2):70-80.
5
The effect of locally applied cholinesterase inhibitors and oximes on the acetylcholinesterase activity in different parts of the guinea-pig eye.局部应用胆碱酯酶抑制剂和肟对豚鼠眼不同部位乙酰胆碱酯酶活性的影响。
Acta Pharmacol Toxicol (Copenh). 1976 Apr;38(4):299-307. doi: 10.1111/j.1600-0773.1976.tb03124.x.
6
A comparative study of central visual field changes induced by sarin vapour and physostigmine eye drops.沙林毒气与毒扁豆碱眼药水引起的中心视野变化的比较研究
Exp Eye Res. 1975 Jan;20(1):15-21. doi: 10.1016/0014-4835(75)90104-9.
7
Interconversion of cholinesterase enzyme activity units by the manual delta pH method and a recommended automated method.
Clin Toxicol. 1976;9(3):353-8. doi: 10.3109/15563657608988136.