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The effect of locally applied cholinesterase inhibitors and oximes on the acetylcholinesterase activity in different parts of the guinea-pig eye.

作者信息

Lund-Karlsen R, Fonnum F

出版信息

Acta Pharmacol Toxicol (Copenh). 1976 Apr;38(4):299-307. doi: 10.1111/j.1600-0773.1976.tb03124.x.

DOI:10.1111/j.1600-0773.1976.tb03124.x
PMID:773106
Abstract
摘要

相似文献

1
The effect of locally applied cholinesterase inhibitors and oximes on the acetylcholinesterase activity in different parts of the guinea-pig eye.局部应用胆碱酯酶抑制剂和肟对豚鼠眼不同部位乙酰胆碱酯酶活性的影响。
Acta Pharmacol Toxicol (Copenh). 1976 Apr;38(4):299-307. doi: 10.1111/j.1600-0773.1976.tb03124.x.
2
Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.使用灌注模型实时测定膜结合乙酰胆碱酯酶活性，比较沙林或对氧磷抑制后恒河猴、猪和豚鼠红细胞乙酰胆碱酯酶肟诱导的重新激活情况。
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3
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes.不同肟类化合物对不同物种沙林抑制的脑乙酰胆碱酯酶的体外重新激活作用
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4
Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain.肟类化合物（解磷定、双复磷、HI-6）对猪脑不同部位中被沙林抑制的乙酰胆碱酯酶的体外重新激活效力比较。
J Appl Toxicol. 2005 Jul-Aug;25(4):271-6. doi: 10.1002/jat.1053.
5
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.拟除虫菊酯和肟类化合物与人、恒河猴、猪、兔、大鼠和豚鼠乙酰胆碱酯酶相互作用的动力学分析。
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Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.使用灌注模型实时测定膜结合乙酰胆碱酯酶活性，比较沙林或对氧磷抑制后肟诱导的红细胞和肌肉乙酰胆碱酯酶的重新激活。
Biochem Pharmacol. 2008 Feb 1;75(3):698-703. doi: 10.1016/j.bcp.2007.09.017. Epub 2007 Sep 21.
7
Characterization of cholinesterases in various tissues of guinea pig with respect to their reactivation by obidoxime after inactivation by diisopropylfluorophosphate.用双异丙基氟磷酸酯使豚鼠各组织中的胆碱酯酶失活后，观察其被氯解磷定重新激活的情况，对各组织中的胆碱酯酶进行表征。
Arch Toxikol. 1972;29(3):235-45. doi: 10.1007/BF00315601.
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A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.通过体外方法比较双吡啶肟——1,4 - 双（2 - 羟基亚氨基甲基吡啶）丁烷二溴化物与目前使用的肟类药物对沙林、塔崩或环沙林抑制的乙酰胆碱酯酶的复活效果。
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9
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?不同沙林和塔崩类似物与人乙酰胆碱酯酶和肟类化合物相互作用的动力学分析：是否存在构效关系？
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10
[Reactivation of O,O-diethylphosphoryl-acetylcholinesterase. Reactivation rephosphorylation equilibrium].[O,O-二乙基磷酰基-乙酰胆碱酯酶的重新活化。重新活化-再磷酸化平衡]
Biochem Pharmacol. 1972 Jan 15;21(2):163-70. doi: 10.1016/0006-2952(72)90266-3.

引用本文的文献

1
Efficacy assessment of a combined anticholinergic and oxime treatment against topical sarin-induced miosis and visual impairment in rats.抗胆碱能药物与肟联合治疗对局部应用沙林诱导大鼠瞳孔缩小和视力损害的疗效评估
Br J Pharmacol. 2014 May;171(9):2364-74. doi: 10.1111/bph.12586.
2
Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection.有机磷化学战剂GA、GB和VX的毒性：对公众防护的意义。
Environ Health Perspect. 1994 Jan;102(1):18-38. doi: 10.1289/ehp.9410218.
3
Accidental exposure to sarin: vision effects.
意外接触沙林：视觉影响。
Arch Toxicol. 1985 Jan;56(3):201-3. doi: 10.1007/BF00333427.
4
Possible mechanisms related to contraction of the bovine iris sphincter in the presence of acetylcholine and carbachol.
Doc Ophthalmol. 1988 Dec;70(4):293-300. doi: 10.1007/BF00157059.
5
Desensitization of the isolated bovine iris sphincter muscles by pilocarpine.毛果芸香碱对离体牛虹膜括约肌的脱敏作用。
Doc Ophthalmol. 1988 May;69(1):73-81. doi: 10.1007/BF00154419.