Owliaee Iman, Khaledian Mehran, Shojaeian Ali, Madanchi Hamid, Yarani Reza, Boroujeni Armin Khaghani, Shoushtari Mohammad
Student Research Committee, Hamadan University of Medical Sciences, Hamadan, 65178-38736, Iran.
Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178-38736, Iran.
Probiotics Antimicrob Proteins. 2025 Jan 7. doi: 10.1007/s12602-024-10430-0.
This review delves into the potential of antimicrobial peptides (AMPs) as promising candidates for combating arboviruses, focusing on their mechanisms of antiviral activity, challenges, and future directions. AMPs have shown promise in preventing arbovirus attachment to host cells, inducing interferon production, and targeting multiple viral stages, illustrating their multifaceted impact on arbovirus infections. Structural elucidation of AMP-viral complexes is explored to deepen the understanding of molecular determinants governing viral neutralization, paving the way for structure-guided design. Furthermore, this review highlights the potential of AMP-based combination therapies to create synergistic effects that enhance overall treatment outcomes while minimizing the likelihood of resistance development. Challenges such as susceptibility to proteases, toxicity, and scalable production are discussed alongside strategies to address these limitations. Additionally, the expanding applications of AMPs as vaccine adjuvants and antiviral delivery systems are emphasized, underscoring their versatility beyond direct antiviral functions.
本综述深入探讨了抗菌肽（AMPs）作为对抗虫媒病毒的有潜力候选物的可能性，重点关注其抗病毒活性机制、挑战及未来方向。抗菌肽在预防虫媒病毒附着于宿主细胞、诱导干扰素产生以及靶向多个病毒阶段方面已显示出前景，说明了它们对虫媒病毒感染的多方面影响。对抗菌肽 - 病毒复合物的结构解析进行了探索，以加深对控制病毒中和的分子决定因素的理解，为基于结构的设计铺平道路。此外，本综述强调了基于抗菌肽的联合疗法产生协同效应的潜力，这种协同效应可提高整体治疗效果，同时将耐药性发展的可能性降至最低。还讨论了诸如对蛋白酶敏感、毒性和可扩展生产等挑战以及应对这些限制的策略。此外，还强调了抗菌肽作为疫苗佐剂和抗病毒递送系统的应用不断扩大，突出了它们除直接抗病毒功能之外的多功能性。
