Li Shu, Fang Hao-Xiang, Wan Lei, Liu Jian
Department of Rheumalogy, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230031, China.
The First Clinical Medical College, Anhui University of Chinese Medicine, Hefei, 230038, China.
Chin J Integr Med. 2025 Jan 8. doi: 10.1007/s11655-025-4207-0.
The prevalence of rheumatoid arthritis (RA) has sharply increased in recent years, posing a serious threat to human health. RA is characterized as a chronic, multisystem disease with morning stiffness and symmetric small joint pain. However, its fundamental processes are poorly understood. With the advancements in molecular biology techniques, a growing body of research indicates that numerous non-coding RNAs (ncRNAs) are essential for the pathogenesis of RA. These ncRNAs not only contribute to the onset of RA but also play a role in the pathological processes of RA development, including synovial immune inflammation and bone destruction. Chinese medicine (single compounds, single herbs, and compound formulae, as well as non-drug therapies such as acupuncture and moxibustion), offer significant benefits for treating RA. This study examined the role of 3 different ncRNA types (circular RNA, long ncRNA, and microRNA) as biomarkers in RA diagnosis, as well as their regulatory roles in rheumatoid arthritis fibroblast-like synoviocytes functions such as inflammatory response, proliferation, cell cycle, apoptosis, and invasion. Additionally, the study explored the mechanisms by which Chinese medicine regulates these ncRNAs, with the goal of offering innovative strategies for RA treatment.
近年来，类风湿关节炎（RA）的患病率急剧上升，对人类健康构成严重威胁。RA的特征是一种慢性多系统疾病，伴有晨僵和对称性小关节疼痛。然而，其基本发病机制仍知之甚少。随着分子生物学技术的进步，越来越多的研究表明，众多非编码RNA（ncRNAs）在RA的发病机制中至关重要。这些ncRNAs不仅促成RA的发病，还在RA发展的病理过程中发挥作用，包括滑膜免疫炎症和骨质破坏。中药（单一化合物、单味草药、复方制剂以及针灸和艾灸等非药物疗法）在治疗RA方面具有显著疗效。本研究考察了3种不同类型的ncRNA（环状RNA、长链非编码RNA和微小RNA）作为RA诊断生物标志物的作用，以及它们对类风湿关节炎成纤维样滑膜细胞功能（如炎症反应、增殖、细胞周期、凋亡和侵袭）的调控作用。此外，该研究还探索了中药调节这些ncRNAs的机制，旨在为RA治疗提供创新策略。
