Reding M, Orto L, Willensky P, Fortuna I, Day N, Steiner S F, Gehr L, McDowell F
Arch Neurol. 1985 Mar;42(3):209-12. doi: 10.1001/archneur.1985.04060030023005.
The dexamethasone suppression test (DST) result was found to be abnormal in 49% of patients who were an average of seven weeks post stroke. The DST response correlated with depressive symptoms as measured by both the Zung and modified Hamilton Depression scales. The specificity of the DST for clinically diagnosed depression reached 87% for the 8 AM cortisol determination, with a corresponding sensitivity of 47%. It was not related to the patient's final level of self-care function as measured by the Barthel score, need for nursing home placement following discharge, or duration of rehabilitation needed to achieve maximum benefit. Abnormal responses were more prevalent in cerebral hemisphere than in brain-stem or cerebellar strokes. The more extensive the stroke the more likely the possibility of an abnormal DST response. The DST response is stable, with test-retest replicability being 84% at two weeks and 74% at seven weeks.
在平均中风后7周的患者中，49%的患者地塞米松抑制试验（DST）结果异常。DST反应与通过Zung量表和改良汉密尔顿抑郁量表测量的抑郁症状相关。对于上午8点的皮质醇测定，DST对临床诊断抑郁症的特异性达到87%，相应的敏感性为47%。它与通过巴氏评分测量的患者最终自我护理功能水平、出院后是否需要入住养老院或获得最大益处所需的康复时间无关。异常反应在大脑半球中风患者中比在脑干或小脑中风患者中更普遍。中风范围越广泛，DST反应异常的可能性就越大。DST反应是稳定的，两周时重测可重复性为84%，七周时为74%。
