Yogakanthi Saiumaeswar, Phan Timothy, Flanagan Emma, Yang Linda, Basnayake Chamara, Thevathasan Iniyaval, Schulberg Julien
Department of Gastroenterology St Vincent's Hospital Melbourne Fitzroy Victoria Australia.
Department of Medicine University of Melbourne Melbourne Victoria Australia.
JGH Open. 2025 Jan 7;9(1):e70091. doi: 10.1002/jgh3.70091. eCollection 2025 Jan.
Acute severe ulcerative colitis (ASUC) in pregnancy poses a clinical challenge with significant risk to both mother and fetus. Anti-TNF alpha therapy is known to be safe in pregnancy, however, data surrounding outcomes in ASUC is limited. In this report, we present the case of a pregnant patient of 10 weeks' gestation with ASUC successfully managed with intensified and accelerated infliximab therapy for a total dose of 35 mg/kg during a single admission. This case highlights the use of this therapeutic strategy, as a part of a multidisciplinary approach, to avoid the need for a high-risk colectomy.
妊娠期急性重症溃疡性结肠炎（ASUC）对母亲和胎儿均构成重大风险，是一项临床挑战。已知抗TNFα疗法在妊娠期是安全的，然而，关于ASUC治疗结果的数据有限。在本报告中，我们介绍了一名妊娠10周的ASUC孕妇病例，该患者在单次住院期间接受强化和加速英夫利昔单抗治疗，总剂量为35mg/kg，成功得到治疗。该病例突出了这种治疗策略作为多学科方法的一部分的应用，以避免进行高风险的结肠切除术。
