Eickhoff T C, Ehret J M
Antimicrob Agents Chemother. 1977 May;11(5):791-6. doi: 10.1128/AAC.11.5.791.
The in vitro activity of netilmicin was compared with that of gentamicin, tobramycin, amikacin, and kanamycin against 636 strains of bacteria recently isolated from clinical sources. Gentamicin was the most active antibiotic, but netilmicin and tobramycin closely paralleled it. Netilmicin was generally four-to eightfold less active than gentamicin against Serratia and group A streptococci, and was twofold less active against Pseudomonas aeruginosa. When effects of inoculum size and concentration of divalent cations in the media were evaluated, netilmicin was shown to be similar to gentamicin in vitro. Minimum inhibitory concentrations for P. aeruginosa were increased as much as 18-fold when the Mg(2+) and Ca(2+) concentrations were increased to physiological levels in Mueller-Hinton broth.
将奈替米星的体外活性与庆大霉素、妥布霉素、阿米卡星和卡那霉素针对最近从临床来源分离出的636株细菌的活性进行了比较。庆大霉素是活性最强的抗生素，但奈替米星和妥布霉素与之相近。奈替米星对沙雷菌属和A组链球菌的活性通常比庆大霉素低4至8倍，对铜绿假单胞菌的活性低2倍。当评估接种量和培养基中二价阳离子浓度的影响时，奈替米星在体外显示与庆大霉素相似。在穆勒-欣顿肉汤中，当镁离子（Mg²⁺）和钙离子（Ca²⁺）浓度增加到生理水平时，铜绿假单胞菌的最低抑菌浓度增加了多达18倍。
