Zheng Zetai, Zhou Hui, Zhang Wenwen, Wang Tingyu, Swamiappan Sathiskumar, Peng Xinsheng, Zhou Yanfang
Department of Pathophysiology, Guangdong Medical University, Dongguan, China.
School of Pharmaceutical Sciences, Guangdong Medical University, Dongguan, China.
Front Cell Dev Biol. 2024 Dec 24;12:1532614. doi: 10.3389/fcell.2024.1532614. eCollection 2024.
In recent years, stem cell therapy has become a pivotal component of regenerative medicine. Stem cells, characterized by their self-renewal capacity and multidirectional differentiation potential, can be isolated from a variety of biological tissues, including adipose tissue, bone marrow, the umbilical cord, and the placenta. The classic applications of stem cells include human pluripotent stem cells (hPSCs) and mesenchymal stem cells (MSCs). However, numerous factors can influence the normal physiological function of stem cells. For instance, in diabetes mellitus, advanced glycation end products (AGEs) accumulate in the extracellular matrix (ECM), impairing the physiological function of stem cells. These substances are closely associated with aging and the progression of numerous degenerative diseases. AGEs can create an environment that is detrimental to the normal physiological functions of stem cells. By binding to the primary cellular receptor for advanced glycation end products (RAGE), AGEs disrupt the physiological activities of stem cells. The binding of RAGE to various ligands triggers the activation of downstream signaling pathways, contributing to the pathophysiological development of diabetes, aging, neurodegenerative diseases, and cancer. Therefore, there is an urgent need for comprehensive research on the impact of AGEs on stem cells, which could provide new insights into the therapeutic application of stem cells in regenerative medicine.
近年来，干细胞疗法已成为再生医学的关键组成部分。干细胞具有自我更新能力和多向分化潜能，可从多种生物组织中分离出来，包括脂肪组织、骨髓、脐带和胎盘。干细胞的经典应用包括人类多能干细胞（hPSCs）和间充质干细胞（MSCs）。然而，众多因素会影响干细胞的正常生理功能。例如，在糖尿病中，晚期糖基化终末产物（AGEs）在细胞外基质（ECM）中积累，损害干细胞的生理功能。这些物质与衰老及多种退行性疾病的进展密切相关。AGEs会营造出对干细胞正常生理功能有害的环境。通过与晚期糖基化终末产物的主要细胞受体（RAGE）结合，AGEs扰乱干细胞的生理活动。RAGE与各种配体的结合会触发下游信号通路的激活，促进糖尿病、衰老、神经退行性疾病和癌症的病理生理发展。因此，迫切需要对AGEs对干细胞的影响进行全面研究，这可为干细胞在再生医学中的治疗应用提供新见解。
