Hou Liwei, Xu Xinyue, Tian Fengchun, Xu Yi
Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba, Chongqing, 400044, China; School of Optoelectronic Engineering, Chongqing University, Shapingba, Chongqing, 400044, China; Chongqing Institute for Food and Drug Control, Chongqing, 401120, China; NMPA Key Laboratory of Quality Monitoring of Anaesthetic and Psychotropic Substances, Chongqing, 401121, China.
Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Chongqing University, Shapingba, Chongqing, 400044, China; School of Optoelectronic Engineering, Chongqing University, Shapingba, Chongqing, 400044, China.
Talanta. 2025 May 1;286:127509. doi: 10.1016/j.talanta.2024.127509. Epub 2025 Jan 1.
The effective qualitative and quantitative detection of mixed components of volatile organic compounds (VOCs) with similar molecular structures has always been a challenge and hotpoint in the research. A novel quartz-crystal microbalance (QCM) nanocomposite sensor integrated with a surface-enhanced Raman scattering (SERS) detection platform for multi-component gas analysis was proposed and fabricated in this paper. MIL-100 (Fe)/PAN composite fibers were developed on QCM via electrospinning of polyacrylonitrile (PAN) and hydrothermal synthesis, addressing the integration issues of MIL-100 particles in devices while maintaining high specific surface area. The MIL-100(Fe)/PAN@QCM sensor can simultaneously collect QCM frequency responses and SERS spectra, enabling the quantitative and qualitative detection of toluene and benzaldehyde in mixtures. The linear response relationship between the frequency obtained by the QCM sensor and the concentration of toluene and benzaldehyde gases was in the range of 0-100 ppm, and the limits of detections were 0.57 and 0.86 ppm, respectively. Additionally, an algorithm, that considered the relationship among the QCM frequency response signal, intensity values of the characteristic peaks in the SERS spectra, and the gas concentration, was developed and applied to measure the mixed gases of toluene and benzaldehyde in the concentration range of 0-100 ppm. The relative standard deviations (RSDs) of spiked sample determinations were found to be in the range of 3-8%. This work provided a new method for the efficient and rapid detection of gas molecules with similar structures, which could be extended and applied to detect more multi-component gas mixtures.
对具有相似分子结构的挥发性有机化合物（VOCs）混合成分进行有效的定性和定量检测一直是该研究领域的挑战和热点。本文提出并制备了一种集成表面增强拉曼散射（SERS）检测平台的新型石英晶体微天平（QCM）纳米复合传感器，用于多组分气体分析。通过静电纺丝聚丙烯腈（PAN）并进行水热合成，在QCM上制备了MIL-100（Fe）/PAN复合纤维，解决了MIL-100颗粒在器件中的集成问题，同时保持了高比表面积。MIL-100（Fe）/PAN@QCM传感器能够同时收集QCM频率响应和SERS光谱，实现对混合物中甲苯和苯甲醛的定量和定性检测。QCM传感器获得的频率与甲苯和苯甲醛气体浓度之间的线性响应关系在0-100 ppm范围内，检测限分别为0.57和0.86 ppm。此外，还开发了一种算法，该算法考虑了QCM频率响应信号、SERS光谱中特征峰的强度值与气体浓度之间的关系，并应用于测量浓度范围为0-100 ppm的甲苯和苯甲醛混合气体。加标样品测定的相对标准偏差（RSD）在3-8%范围内。这项工作为高效快速检测结构相似的气体分子提供了一种新方法，可扩展应用于检测更多的多组分气体混合物。
