Lu Beibei, Fu Yuanyuan, Liu Youting, Zhang Zhaolun, Chen Yong, Zhan Jingbo, Zhang Jianglin, Zhang Jiaheng
School of Pharmacy, Guangzhou Huali College, Guangzhou 511325, China; Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China; Sauvage Laboratory for Smart Materials, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China; Research Centre of Printed Flexible Electronics, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Beijing Uproven Medical Technology Co. Ltd., Beijing 102600, China.
Int J Biol Macromol. 2025 Mar;294:139523. doi: 10.1016/j.ijbiomac.2025.139523. Epub 2025 Jan 6.
In the field of cosmetics, epigallocatechin gallate (EGCG) is highly valued for its multiple effects such as delaying photoaging, whitening, anti-allergy, acne removal, astringency, and moisturizing. However, due to the active chemical properties of EGCG, there are challenges in terms of stability and transdermal absorption, which limits its widespread application in cosmetics. Therefore, we utilized supramolecular modification technology to form supramolecular carboxymethyl chitosan-EGCG-trehalose (CC-EGCG) by combining EGCG with carboxymethyl chitosan and trehalose, enhancing its stability. Then, we encapsulated the supramolecular CC-EGCG with hydroxypropyl cyclodextrin to obtain a dual supramolecular CC-EGCG, which not only further enhanced the stability of the raw material and reduced its irritation to the skin but also improved skin permeability (compared with single EGCG, the dual supramolecular CC-EGCG increased by 3.51 times). The bioavailability of EGCG was significantly improved, making it play a better role in antioxidant, whitening, soothing, and oil control acne removal.
在化妆品领域，表没食子儿茶素没食子酸酯（EGCG）因其具有延缓光老化、美白、抗过敏、祛痘、收敛和保湿等多种功效而备受重视。然而，由于EGCG具有活跃的化学性质，在稳定性和透皮吸收方面存在挑战，这限制了其在化妆品中的广泛应用。因此，我们利用超分子修饰技术，将EGCG与羧甲基壳聚糖和海藻糖结合，形成超分子羧甲基壳聚糖 - EGCG - 海藻糖（CC - EGCG），增强其稳定性。然后，我们用羟丙基环糊精包裹超分子CC - EGCG，得到双超分子CC - EGCG，它不仅进一步提高了原料的稳定性，降低了对皮肤的刺激性，还提高了皮肤渗透性（与单一EGCG相比，双超分子CC - EGCG提高了3.51倍）。EGCG的生物利用度显著提高，使其在抗氧化、美白、舒缓和控油祛痘方面发挥更好的作用。
