Rizwan Amber, Aqeel Aatiquah, Idris Aisha, Farooqi Humaira
Department of Biotechnology, Jamia Hamdard, New Delhi, 110062, India.
Anticancer Agents Med Chem. 2025;25(8):544-554. doi: 10.2174/0118715206341220241120132600.
This review investigates the outcome of heavy metal contamination on the anti-cancer properties of medicinal plants. Heavy metal pollution is a significant environmental concern globally, often found in soil and water due to industrial activities. Therapeutic plants are recognized because of their therapeutic attributes and their ability to absorbing these contaminants. This study examines how heavy metal exposure modifies the chemical composition and efficacy of medicinal plants against cancer cells. Through a comprehensive review of existing literature and experimental analysis, we explore the mechanisms by which heavy metals interact with bioactive compounds in medicinal plants, affecting their anti-cancer potency. Findings reveal intricate interactions among heavy metals and phytochemicals, leading to variations in cytotoxicity against cancer cells. Comprehending these interactions is crucial for optimizing the utilization of medicinal plants in cancer treatment and for developing approaches to alleviate the impacts of heavy metal contamination on their therapeutic potential. The urgency of this issue cannot be overstated, as it directly impacts our ability to effectively treat cancer and preserve our environment.
本综述研究了重金属污染对药用植物抗癌特性的影响。重金属污染是全球重大的环境问题，由于工业活动，常存在于土壤和水中。药用植物因其治疗特性以及吸收这些污染物的能力而受到认可。本研究考察了重金属暴露如何改变药用植物的化学成分及其对癌细胞的疗效。通过对现有文献的全面综述和实验分析，我们探究了重金属与药用植物中生物活性化合物相互作用的机制，及其对药用植物抗癌效力的影响。研究结果揭示了重金属与植物化学物质之间复杂的相互作用，导致对癌细胞的细胞毒性发生变化。理解这些相互作用对于优化药用植物在癌症治疗中的应用以及开发减轻重金属污染对其治疗潜力影响的方法至关重要。这个问题的紧迫性再怎么强调也不为过，因为它直接影响我们有效治疗癌症和保护环境的能力。
