卵巢内注射富含血小板血浆可显著提高体外受精患者的囊胚产量和质量。
Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients.
作者信息
Yu Tzu-Ning, Chen Ming-Jer, Lee Tsung-Hsien, Chen Yi-Chun, Cheng En-Hui, Huang Chun-Chia, Chen Chung-I, Lee Chun-I, Lee Maw-Sheng, Lin Pin-Yao
机构信息
Division of Infertility, Lee Women's Hospital, Taichung City, 406, Taiwan.
Department of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, Taichung City, 407, Taiwan.
出版信息
Sci Rep. 2025 Jan 8;15(1):1301. doi: 10.1038/s41598-024-82630-1.
This study evaluated the effectiveness of intraovarian platelet-rich plasma (PRP) injection in improving ovarian response and embryo quality in IVF patients with poor embryo quality in previous controlled ovarian hyperstimulation (COH) cycles. 74 patients participated, with 30 in the control group and 44 in the PRP group. PRP was injected during the follicular phase for the PRP group. The control group completed two COH cycles, while the PRP group underwent COH cycles before and after the PRP injection. In the first COH cycle, there were no significant differences between groups. However, in the second COH cycle, the PRP group showed significant improvements: the number of fertilized oocytes increased (5.2 ± 3.6 vs. 3.3 ± 3.5, p = 0.011), total blastocysts (1.7 ± 1.5 vs. 0.5 ± 0.7, p < 0.0001) and good quality blastocysts (0.6 ± 0.8 vs. 0 ± 0.2, P < 0.0001). The total blastocyst rate (35 ± 31% vs. 13 ± 24%, p = 0.001) and good quality blastocyst rate (14 ± 22% vs. 1 ± 3%, p < 0.0001) were also higher in the PRP group. The most notable benefits occurred when COH was conducted one to two months post-PRP injection.
本研究评估了卵巢内注射富血小板血浆（PRP）对改善既往控制性卵巢过度刺激（COH）周期中胚胎质量较差的体外受精（IVF）患者卵巢反应及胚胎质量的有效性。74例患者参与研究，其中对照组30例，PRP组44例。PRP组在卵泡期注射PRP。对照组完成两个COH周期，而PRP组在注射PRP前后均进行COH周期。在第一个COH周期中，两组间无显著差异。然而，在第二个COH周期中，PRP组有显著改善：受精卵子数量增加（5.2±3.6对3.3±3.5，p = 0.011），囊胚总数（1.7±1.5对0.5±0.7，p < 0.0001）以及优质囊胚数量（0.6±0.8对0±0.2，P < 0.0001）。PRP组的囊胚总率（35±31%对13±24%，p = 0.001）和优质囊胚率（14±22%对1±3%，p < 0.0001）也更高。最显著的益处出现在PRP注射后1至2个月进行COH时。
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