Xiong Huali, Zhao Peng, Ma Fengxun, Tang Dayi, Liu Daiqiang
Center for mental health of Rongchang District, Chongqing, China.
Department of Public Health, Health Commission of Rongchang District, Chongqing, China.
Sci Rep. 2025 Jan 8;15(1):1332. doi: 10.1038/s41598-025-85367-7.
Limited studies have been conducted on the interaction of smoking and abdominal obesity on the risk of pre-diabetes mellitus (PDM) among rural adults in southwest China. The data was obtained from a cross-sectional survey conducted using a two stage random sampling method around Rongchang district in ChongQing municipality southwest of China in 2022. A total of 3,017 participants aged 40 to 79 years old were included in the study. Multivariate logistic regression analyses were performed to evaluate the associated risk factors for PDM, and the effect of multiplicative and additive interactions between smoking and abdominal obesity were also assessed by indicators including the relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP) and the synergy index (SI). We found that the prevalence of PDM in participants was 38.98% with an average age of (62.14 ± 11.13) years. Following adjustments for confounding variables, current smoking (OR = 1.26, 95%CI:1.04-1.52) and abdominal obesity (OR = 1.4, 95%CI:1.18-1.66) were significantly linked to an elevated risk of PDM. The multiplicative interaction analyses demonstrated that current smoking exhibited a positive association with PDM (OR = 1.32, 95%CI:1.01-1.71), while a similar association was not observed in the case of abdominal obesity with PDM (OR = 1.15, 95%CI:0.94-1.4). A significant additive interaction was observed between current smoking and abdominal obesity in terms of PDM risk (OR = 3.56, 95% CI: 2.54-4.98). The RERI = 2.09(0.95-3.24), indicating a coexisting risk attributable to additive interaction; the AP = 0.59(0.43-0.75), indicating that 59% of all PDM individuals exposed to both risk factors could be attributed to the synergistic effect of current smoking and abdominal obesity; the SI = 5.51(2.15-14.1), suggesting that the synergistic risk between current smoking and abdominal obesity was 5.51times greater than the sum of effects observed in individuals exposed to a single factor alone. The prevalence of PDM in Rongchang, potentially indicating a higher future incidence of diabetes mellitus. It is noteworthy that smoking and abdominal obesity exhibit a positive synergistic effect on the risk of PDM.
在中国西南部农村成年人中，关于吸烟与腹型肥胖对糖尿病前期（PDM）风险的相互作用的研究有限。数据来自于2022年在中国西南部重庆市荣昌区周边采用两阶段随机抽样方法进行的横断面调查。共有3017名年龄在40至79岁之间的参与者被纳入研究。进行多因素逻辑回归分析以评估PDM的相关危险因素，并通过包括交互作用所致相对超额危险度（RERI）、交互作用所致归因比例（AP）和协同指数（SI）等指标评估吸烟与腹型肥胖之间相乘和相加交互作用的效应。我们发现参与者中PDM的患病率为38.98%，平均年龄为（62.14±11.13）岁。在对混杂变量进行调整后，当前吸烟（OR = 1.26，95%CI：1.04 - 1.52）和腹型肥胖（OR = 1.4，95%CI：1.18 - 1.66）与PDM风险升高显著相关。相乘交互作用分析表明，当前吸烟与PDM呈正相关（OR = 1.32，95%CI：1.01 - 1.71），而腹型肥胖与PDM之间未观察到类似关联（OR = 1.15，95%CI：0.94 -
