Beracochea D, Jaffard R
Behav Brain Res. 1985 Jan;15(1):15-25. doi: 10.1016/0166-4328(85)90014-2.
Male mice of the BALB/c strain were given a solution of 15% ethanol as their only source of fluid for periods varying from 5 weeks to 8 months. For behavioral testing, they were compared with control groups which had received either an isocaloric solution of sucrose or tap water. Memory was tested by using spontaneous alternation behavior in a T maze. Each test consisted of two forced trials (acquisition) followed by a free trial (test) given at different acquisition--test intervals (from 30 s to 24 h). Results from two independent experiments showed that after 25 weeks of ethanol administration there was an accelerated rate of decay of spontaneous alternation as a function of the acquisition--test interval. Such a phenomenon persisted after ethanol was omitted from the diet. A third experiment showed that when tested on two successive sessions separated by a 5 h interval, experimental subjects exhibited a decreased ability to perform normally on the second test. Our data are interpreted as showing that long-term ethanol administration results in accelerated forgetting and increased vulnerability to proactive interference and, as such, they are compared to the memory dysfunctions observed in amnesic patients.
给BALB/c品系的雄性小鼠提供15%乙醇溶液作为唯一的液体来源，持续时间从5周至8个月不等。为了进行行为测试，将它们与接受等热量蔗糖溶液或自来水的对照组进行比较。通过在T迷宫中使用自发交替行为来测试记忆。每次测试包括两次强制试验（习得），随后是在不同的习得 - 测试间隔（从30秒到24小时）进行的一次自由试验（测试）。两项独立实验的结果表明，给予乙醇25周后，自发交替的衰退速率随着习得 - 测试间隔而加快。从饮食中去除乙醇后，这种现象仍然存在。第三个实验表明，当在间隔5小时的两个连续时段进行测试时，实验对象在第二次测试中表现出正常执行能力下降。我们的数据被解释为表明长期给予乙醇会导致遗忘加速和对前摄干扰的易感性增加，因此，将它们与在失忆症患者中观察到的记忆功能障碍进行比较。
