Beracochea D, Jaffard R
C R Seances Acad Sci III. 1983;296(11):535-40.
Male Mice of the BALB/c strain were given a solution of 15% ethanol as its only source of fluid for 8 months. 2 months after alcohols was omitted from the diet they were tested for memory and compared to two control groups which received either an isocaloric solution of sucrose or tap water. Memory was tested by using spontaneous alternation (S.A.) in a T maze as a learning paradigm involving two forced trials (acquisition) followed by a free trial (retention). The 1st experiment was aimed at studying the spontaneous alteration rate as a function of the acquisition-test interval. It was found that for a short interval (5 min) the S.A. rate did not differ between the experimental aid control subjects but that it decreases more rapidly over time (1 h and 24 h) in alcohol treated subjects. The second experiment was aimed at determining whether this accelerated forgetting might not be explained by an excess of proactive interference. Results showed that when experimental subjects remembered for 1 h informations associated with a first acquisition, they were no longer able to remember those associated with a second acquisition when the interval between the two acquisitions was 5 h. Such proactive interference was not found in control subjects. These results suggest that, as in humans, prolonged alcohol consumption results in accelerated forgetting and increased proactive interferences.
将BALB/c品系的雄性小鼠给予15%乙醇溶液作为其唯一的液体来源，持续8个月。在从饮食中去除酒精2个月后，对它们进行记忆测试，并与两个对照组进行比较，这两个对照组分别接受等热量的蔗糖溶液或自来水。通过在T迷宫中使用自发交替（S.A.）作为学习范式来测试记忆，该范式包括两次强制试验（习得），然后是一次自由试验（保持）。第一个实验旨在研究自发交替率作为习得-测试间隔的函数。结果发现，对于短间隔（5分钟），实验对象和对照对象之间的S.A.率没有差异，但在酒精处理的对象中，随着时间推移（1小时和24小时），S.A.率下降得更快。第二个实验旨在确定这种加速遗忘是否不能用过多的前摄干扰来解释。结果表明，当实验对象记住与第一次习得相关的信息1小时后，当两次习得之间的间隔为5小时时，他们不再能够记住与第二次习得相关的信息。在对照对象中未发现这种前摄干扰。这些结果表明，与人类一样，长期饮酒会导致加速遗忘和增加前摄干扰。
