Beracochea D, Lescaudron L, Tako A, Verna A, Jaffard R
Behav Brain Res. 1987 Jul;25(1):63-74. doi: 10.1016/0166-4328(87)90045-3.
Male mice of the BALB/c strain were given a solution of 15% ethanol as their only source of fluid during either 24 or 48 weeks. They were submitted to a sequential alternation (SA) task in a T-maze (6 successive trials). It was found that 48 but not 24 weeks of alcohol administration lead to a deficit as compared to pair-fed or tap-water controls. Whereas experimental mice performed as well as controls on the first 3 choices, they exhibited a gradual decrease in the SA rate on subsequent trials. We suggest that this deficit might result from an exaggerated vulnerability to proactive interference (PI). In order to further test this hypothesis, a second experiment investigated whether a between-trials variation of context of the maze would increase performance. It was found that the SA rate improved as soon as the variation was provided (5th trial). We suggest that the deficit of experimental mice results from an impairment of retrieval processes. A neuroanatomical study was conducted to quantify cell losses resulting from 8, 24 or 48 weeks of ethanol treatment in the mammillary bodies (MM) or the hippocampus (HPC). At the time of appearance of the deficit, MM exhibited a -32% cellular loss, whereas this was only -18% in the HPC. This result emphasises the importance of MM lesion in memory deficits resulting from long-term alcohol consumption.
给BALB/c品系的雄性小鼠提供15%乙醇溶液作为其仅有的液体来源，持续24周或48周。将它们置于T型迷宫中进行连续交替（SA）任务（6次连续试验）。结果发现，与成对喂食或自来水对照组相比，给予酒精48周而非24周会导致缺陷。虽然实验小鼠在前3次选择中的表现与对照组一样，但在随后的试验中，它们的SA率逐渐下降。我们认为这种缺陷可能是由于对前摄干扰（PI）的过度易感性所致。为了进一步验证这一假设，第二个实验研究了迷宫情境在试验间的变化是否会提高表现。结果发现，一旦提供这种变化（第5次试验），SA率就会提高。我们认为实验小鼠的缺陷是由于检索过程受损所致。进行了一项神经解剖学研究，以量化在乳头体（MM）或海马体（HPC）中，8周、24周或48周乙醇处理导致的细胞损失。在缺陷出现时，MM表现出32%的细胞损失，而HPC中仅为18%。这一结果强调了MM损伤在长期饮酒导致的记忆缺陷中的重要性。
