Wang Bo, Chen Dongwei, Chen Hua, Wu Wei, Cheng Kaiyi, Tao Yixiu, Zhang Ling, Liu Ce, Ou Ding, Zhang Mingxiu, Tang Xianmei, Wang Shouli, Wang Guangzhu, Luo Bin
Department of Hospital Infection Control, Hanzhong Central Hospital, Hanzhong, Shaanxi, 723000, China.
Administrative Office, Hanzhong Central Hospital, Hanzhong, Shaanxi, 723000, China.
BMC Public Health. 2025 Jan 8;25(1):100. doi: 10.1186/s12889-024-21270-6.
Enteric infections are among the most common infectious diseases. The aim of this article was to track the global trends in morbidity and mortality from enteric infections in 204 countries or territories from 1990 to 2019.
Data were obtained from the Global Burden of Disease 2019 study. Average annual percentage changes (AAPCs) in age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) were calculated to quantify trends in enteric infections. Age-period-cohort models were used to estimate the annual percentage changes from 0 to 4 to 80 - 84 years (local drifts), period and cohort effects between 1990 and 2019 in different socio-demographic index (SDI) regions.
In 2019, there were 6.59 billion incident cases of enteric infections, and caused 1,748,251 deaths worldwide. From 1990 to 2019, the trend in the global ASIR of enteric infections was relatively stable, but that of ASMR declined (AAPC=-3.30, 95% confidence interval [CI]: -3.54 to -3.07), and global mortality decreased in all age groups. Meanwhile, decreasing trends in ASMR were observed in 173 countries/territories (P < 0.05), particularly in North Macedonia and Kazakhstan. The low and low-middle SDI areas showed decreasing trends in ASIR and ASMR for enteric infections. However, an increasing trend was observed in high SDI regions, especially among older people aged over 60 years.
The global incidence of enteric infections did not change significantly between 1990 and 2019, but the mortality showed a significantly downward trend. The global burden of enteric infections remains serious in children under 5 years and in low and low-middle SDI regions.
肠道感染是最常见的传染病之一。本文旨在追踪1990年至2019年204个国家或地区肠道感染发病率和死亡率的全球趋势。
数据来自《2019年全球疾病负担》研究。计算年龄标准化发病率（ASIR）和年龄标准化死亡率（ASMR）的年均百分比变化（AAPC），以量化肠道感染趋势。采用年龄-时期-队列模型估计1990年至2019年不同社会人口指数（SDI）地区0至4岁、80至84岁（局部漂移）、时期和队列效应的年百分比变化。
2019年，全球有65.9亿例肠道感染病例，导致1748251人死亡。1990年至2019年，全球肠道感染ASIR趋势相对稳定，但ASMR呈下降趋势（AAPC=-3.30，95%置信区间[CI]：-3.54至-3.07），所有年龄组的全球死亡率均下降。同时，173个国家/地区的ASMR呈下降趋势（P<0.05），尤其是北马其顿和哈萨克斯坦。低SDI和中低SDI地区肠道感染的ASIR和ASMR呈下降趋势。然而，高SDI地区呈上升趋势，尤其是60岁以上的老年人。
1990年至2019年，全球肠道感染发病率无显著变化，但死亡率呈显著下降趋势。5岁以下儿童以及低SDI和中低SDI地区的全球肠道感染负担仍然严重。
