Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Curr Opin Microbiol. 2020 Feb;53:19-25. doi: 10.1016/j.mib.2020.01.016. Epub 2020 Feb 20.
Clostridioides difficile is the leading cause of hospital-acquired gastrointestinal infections and a major public health burden in the United States. C. difficile infection causes a spectrum of disease from mild diarrhea to severe complications such as pseudomembranous colitis, toxic megacolon and death. This broad range of disease is only partially explained by bacterial genetic factors, host genetics, comorbidities and previous drug exposures. Another important factor is the gut microbiome, the disruption of which results in a loss of colonization resistance to C. difficile. Here, we review how gut microbiota and their metabolites impact C. difficile virulence and influence disease.
艰难梭菌是美国医院获得性胃肠道感染的主要原因，也是一个主要的公共卫生负担。艰难梭菌感染导致一系列疾病，从轻度腹泻到严重并发症，如伪膜性结肠炎、中毒性巨结肠和死亡。这种广泛的疾病仅部分由细菌遗传因素、宿主遗传因素、合并症和先前的药物暴露来解释。另一个重要因素是肠道微生物组，其破坏导致对艰难梭菌的定植抵抗力丧失。在这里，我们回顾了肠道微生物群及其代谢物如何影响艰难梭菌的毒力并影响疾病。
