• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons.人肝微粒体中香豆素7-羟化酶活性。该酶的特性及种间比较。
Br J Clin Pharmacol. 1985 Jan;19(1):59-66. doi: 10.1111/j.1365-2125.1985.tb02613.x.
2
Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation.肝脏微粒体细胞色素P450 2A酶的种属差异和个体间变异：对香豆素、双香豆素和睾酮氧化的影响。
Arch Biochem Biophys. 1992 Oct;298(1):211-25. doi: 10.1016/0003-9861(92)90115-d.
3
Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse liver.从小鼠肝脏中纯化和鉴定具有高香豆素7-羟化酶活性的微粒体细胞色素P-450
Eur J Biochem. 1984 Nov 2;144(3):425-31. doi: 10.1111/j.1432-1033.1984.tb08483.x.
4
Biochemical characterization of coumarin 7-hydroxylase activity in chick embryo liver microsomes.鸡胚肝微粒体中香豆素7-羟化酶活性的生化特性
Biochem Pharmacol. 1992 Jan 22;43(2):363-9. doi: 10.1016/0006-2952(92)90299-x.
5
Inhibition of coumarin 7-hydroxylase activity in human liver microsomes.人肝微粒体中香豆素7-羟化酶活性的抑制作用。
Arch Biochem Biophys. 1997 May 1;341(1):47-61. doi: 10.1006/abbi.1997.9964.
6
Pyrazole is different from acetone and ethanol as an inducer of the polysubstrate monooxygenase system in mice: evidence that pyrazole-inducible P450Coh is distinct from acetone-inducible P450ac.吡唑作为小鼠多底物单加氧酶系统的诱导剂，与丙酮和乙醇不同：有证据表明吡唑诱导的P450Coh与丙酮诱导的P450ac不同。
Arch Biochem Biophys. 1988 Dec;267(2):589-98. doi: 10.1016/0003-9861(88)90066-5.
7
Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6.毛果芸香碱对香豆素7-羟化的竞争性抑制作用及其与小鼠CYP 2A5和人CYP 2A6的相互作用。
Br J Pharmacol. 1995 Nov;116(6):2625-30. doi: 10.1111/j.1476-5381.1995.tb17217.x.
8
Cytochrome P4502A-mediated coumarin 7-hydroxylation and testosterone hydroxylation in mouse and rat lung.细胞色素P4502A介导的香豆素在小鼠和大鼠肺中的7-羟基化及睾酮羟基化作用。
Pharmacol Toxicol. 1993 Feb;72(2):107-12. doi: 10.1111/j.1600-0773.1993.tb00299.x.
9
Correlations between cytochrome P-450 and oxidative metabolism of benzo[a]pyrene and 7-ethoxycoumarin in human liver in vitro and antipyrine elimination in vivo.体外人肝脏中细胞色素P-450与苯并[a]芘和7-乙氧基香豆素氧化代谢及体内安替比林消除之间的相关性。
Drug Metab Dispos. 1980 Jul-Aug;8(4):218-22.
10
Comparison of CYP2A6 catalytic activity on coumarin 7-hydroxylation in human and monkey liver microsomes.人及猴肝微粒体中CYP2A6对香豆素7-羟化催化活性的比较。
Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):295-304. doi: 10.1007/BF03190960.

引用本文的文献

1
Long-Term Engineered Cultures of Primary Mouse Hepatocytes for Strain and Species Comparison Studies During Drug Development.用于药物开发期间品系和物种比较研究的原代小鼠肝细胞长期工程培养物。
Gene Expr. 2019 Nov 4;19(3):199-214. doi: 10.3727/105221619X15638857793317. Epub 2019 Jul 24.
2
Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.小鼠肝脏中Cyp2a5表达和活性的品系间差异。
BMC Res Notes. 2017 Mar 15;10(1):125. doi: 10.1186/s13104-017-2435-x.
3
Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6 15, CYP2A6 16, CYP2A6 21 and CYP2A6 22: differential susceptibility due to different sequence locations of the mutations.8-甲氧基补骨脂素对细胞色素 P450 2A6（CYP2A6）等位变体 CYP2A6 15、CYP2A6 16、CYP2A6 21 和 CYP2A6 22 的抑制效力：由于突变的不同序列位置导致的不同敏感性。
PLoS One. 2014 Jan 27;9(1):e86230. doi: 10.1371/journal.pone.0086230. eCollection 2014.
4
Comparison of CYP2A6 catalytic activity on coumarin 7-hydroxylation in human and monkey liver microsomes.人及猴肝微粒体中CYP2A6对香豆素7-羟化催化活性的比较。
Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):295-304. doi: 10.1007/BF03190960.
5
Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6.毛果芸香碱对香豆素7-羟化的竞争性抑制作用及其与小鼠CYP 2A5和人CYP 2A6的相互作用。
Br J Pharmacol. 1995 Nov;116(6):2625-30. doi: 10.1111/j.1476-5381.1995.tb17217.x.
6
Interindividual variability of coumarin 7-hydroxylation in a Turkish population.土耳其人群中香豆素7-羟化作用的个体间变异性。
Eur J Clin Pharmacol. 1994;47(4):315-8. doi: 10.1007/BF00191161.
7
The inhibition of CYP enzymes in mouse and human liver by pilocarpine.毛果芸香碱对小鼠和人肝脏中细胞色素P450酶的抑制作用。
Br J Pharmacol. 1995 Feb;114(4):832-6. doi: 10.1111/j.1476-5381.1995.tb13279.x.
8
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.香豆素7-羟化作用中的一种基因多态性：人类CYP2A基因序列及变异型CYP2A6等位基因的鉴定。
Am J Hum Genet. 1995 Sep;57(3):651-60.
9
The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies.吸烟对人肝脏中7-乙氧基试卤灵O-脱乙基酶及其他单加氧酶活性的影响：用单克隆抗体进行分析
Br J Clin Pharmacol. 1986 Aug;22(2):125-34. doi: 10.1111/j.1365-2125.1986.tb05239.x.
10
Activation mechanisms to chemical toxicity.化学毒性的激活机制。
Arch Toxicol. 1987;60(1-3):5-15. doi: 10.1007/BF00296939.

本文引用的文献

1
Comparison of the hydroxylation of benzo(a)pyrene with the metabolism of vinyl chloride, N-nitrosomorpholine, and N-nitroso-N'-methylpiperazine to mutagens by human and rat liver microsomal fractions.人及大鼠肝脏微粒体组分对苯并(a)芘羟基化作用与氯乙烯、N-亚硝基吗啉及N-亚硝基-N'-甲基哌嗪代谢生成诱变剂的比较。
Cancer Res. 1980 Jan;40(1):119-26.
2
The selective activation of cytochrome P-450 dependent microsomal hydroxylases in human and rat liver microsomes.人及大鼠肝脏微粒体中细胞色素P - 450依赖性微粒体羟化酶的选择性激活。
Biochem Pharmacol. 1981 Jun 15;30(12):1702-3. doi: 10.1016/0006-2952(81)90401-9.
3
Metabolism of two beta-adrenoceptor antagonists, alprenolol and metoprolol, in different species. In-vitro and in-vivo correlations.两种β-肾上腺素能受体拮抗剂阿普洛尔和美托洛尔在不同物种中的代谢。体外和体内相关性。
Acta Pharm Suec. 1980;17(5):295-6.
4
Monooxygenase activities of human liver, lung, and kidney microsomes - a study of 42 post mortem cases.人肝脏、肺和肾脏微粒体的单加氧酶活性——42例尸检病例研究
Acta Pharmacol Toxicol (Copenh). 1982 May;50(5):332-41. doi: 10.1111/j.1600-0773.1982.tb00984.x.
5
Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies.利用单克隆抗体对人体组织中的细胞色素P-450进行表型分析。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3682-6. doi: 10.1073/pnas.79.12.3682.
6
Drug metabolism in human liver in vitro: establishment of a human liver bank.人肝脏体外药物代谢：人肝脏库的建立
Clin Pharmacol Ther. 1980 Jun;27(6):711-25. doi: 10.1038/clpt.1980.102.
7
Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.人肝脏针吸活检标本微粒体组分中的单加氧酶活性
Br J Clin Pharmacol. 1980 Jan;9(1):11-9. doi: 10.1111/j.1365-2125.1980.tb04790.x.
8
Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes.从人肝微粒体中纯化和鉴定六种细胞色素P-450同工酶。
Biochemistry. 1983 Nov 8;22(23):5375-83. doi: 10.1021/bi00292a019.
9
Correlations between cytochrome P-450 and oxidative metabolism of benzo[a]pyrene and 7-ethoxycoumarin in human liver in vitro and antipyrine elimination in vivo.体外人肝脏中细胞色素P-450与苯并[a]芘和7-乙氧基香豆素氧化代谢及体内安替比林消除之间的相关性。
Drug Metab Dispos. 1980 Jul-Aug;8(4):218-22.
10
Metabolism of coumarin and 4-methylcoumarin by rat-liver microsomes.大鼠肝脏微粒体对香豆素和4-甲基香豆素的代谢
Can J Biochem. 1971 Feb;49(2):177-84. doi: 10.1139/o71-026.

人肝微粒体中香豆素7-羟化酶活性。该酶的特性及种间比较。

Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons.

作者信息

Pelkonen O, Sotaniemi E A, Ahokas J T

出版信息

Br J Clin Pharmacol. 1985 Jan;19(1):59-66. doi: 10.1111/j.1365-2125.1985.tb02613.x.

DOI:10.1111/j.1365-2125.1985.tb02613.x
PMID:3978021
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463777/
Abstract

Coumarin 7-hydroxylation and other cytochrome P-450-associated enzyme activities were studied in human liver biopsy homogenates and compared with activities in livers of other species. Coumarin 7-hydroxylation is extraordinarily active in human liver biopsy samples in vitro. Activity is lower in mouse, rabbit or guinea pig liver and essentially absent in rat liver. Cytochrome P-450 content and other associated enzyme activities were higher in animals. Coumarin 7-hydroxylation is induced by phenobarbitone in mouse liver, but no significant increase was seen in human or rat liver after exposure to inducers. Correlations amongst coumarin 7-hydroxylase, aryl hydrocarbon hydroxylase, 7-ethoxycoumarin O-deethylase and cytochrome P-450 are statistically significant (r values from 0.56 to 0.73), but do not permit the conclusion, that the same P-450 form catalyzes all the reactions studied. The correlations between coumarin hydroxylation and antipyrine half-life or clearance are statistically significant, but not good enough for predictive purposes. Coumarin 7-hydroxylase in human liver is inhibited by alpha-naphthoflavone, SKF 525A, metyrapone and aniline.

摘要

在人肝活检匀浆中研究了香豆素7-羟化作用及其他与细胞色素P-450相关的酶活性，并与其他物种肝脏中的活性进行了比较。香豆素7-羟化作用在人肝活检样本的体外实验中异常活跃。在小鼠、兔子或豚鼠肝脏中活性较低，而在大鼠肝脏中基本没有活性。动物体内细胞色素P-450含量及其他相关酶活性较高。香豆素7-羟化作用在小鼠肝脏中可被苯巴比妥诱导，但在人或大鼠肝脏中接触诱导剂后未见明显增加。香豆素7-羟化酶、芳烃羟化酶、7-乙氧基香豆素O-脱乙基酶和细胞色素P-450之间的相关性具有统计学意义（r值为0.56至0.73），但不能得出同一细胞色素P-450形式催化所有所研究反应的结论。香豆素羟化作用与安替比林半衰期或清除率之间的相关性具有统计学意义，但用于预测目的还不够理想。人肝脏中的香豆素7-羟化酶受到α-萘黄酮、SKF 525A、甲吡酮和苯胺的抑制。