Jonkman J H, van der Boon W J, Schoenmaker R, Holtkamp A, Hempenius J
Br J Clin Pharmacol. 1985 Jan;19(1):99-101. doi: 10.1111/j.1365-2125.1985.tb02620.x.
The effect of the antibiotic drug amoxicillin on steady state pharmacokinetics of theophylline was studied in healthy adults by comparing the pharmacokinetic parameters as found during a 9 day course of theophylline alone and as obtained during comedication with amoxicillin. Theophylline plasma concentrations were measured by means of h.p.l.c. analysis. On the ninth day of each of the two periods of drug administration a concentration-time curve was evaluated. It showed no influence of amoxicillin on absorption, elimination and volume of distribution of theophylline, as a result of which mean steady state plasma concentrations were not significantly different during both treatments. It is concluded that both drugs can be given concomitantly without any dosage adjustment of theophylline.
通过比较单独使用茶碱9天疗程期间以及与阿莫西林联合用药期间的药代动力学参数，研究了抗生素药物阿莫西林对健康成年人中茶碱稳态药代动力学的影响。茶碱血浆浓度通过高效液相色谱分析进行测定。在两个给药期的每一期的第9天，对浓度-时间曲线进行了评估。结果显示阿莫西林对茶碱的吸收、消除和分布容积没有影响，因此在两种治疗期间平均稳态血浆浓度没有显著差异。得出的结论是，两种药物可以同时给药，而无需对茶碱进行任何剂量调整。
