Jonkman J H, van der Boon W J, Schoenmaker R, Holtkamp A H, Hempenius J
Chemotherapy. 1985;31(5):329-35. doi: 10.1159/000238356.
The influence of amoxycillin and theophylline on their mutual steady-state pharmacokinetics was studied in healthy adults by comparing the pharmacokinetic parameters as obtained during a 10-day course of each drug alone and after giving the drugs in combination. Amoxycillin and theophylline plasma concentrations were measured by means of HPLC methods. On the 9th day of each of the two periods of drug administration, a concentration-time curve was evaluated. These showed no influence of theophylline on absorption, elimination or volume of distribution of amoxycillin, demonstrating that the mean steady-state plasma concentrations were not significantly different during the two treatments. Amoxycillin also has no significant effect on theophylline steady-state pharmacokinetics. It is concluded that both drugs can be given concomitantly without any dosage adjustment.
通过比较单独使用每种药物10天疗程期间以及联合给药后获得的药代动力学参数，研究了阿莫西林和茶碱对彼此稳态药代动力学的影响。采用高效液相色谱法测定阿莫西林和茶碱的血浆浓度。在两个给药期的第9天，评估浓度-时间曲线。结果表明，茶碱对阿莫西林的吸收、消除或分布容积没有影响，这表明两种治疗期间的平均稳态血浆浓度没有显著差异。阿莫西林对茶碱的稳态药代动力学也没有显著影响。结论是两种药物可以同时给药，无需调整剂量。
