Jonkman J H, Van der Boon W J, Schoenmaker R, Holtkamp A H, Hempenius J
J Pharm Sci. 1985 Oct;74(10):1103-4. doi: 10.1002/jps.2600741019.
In an open cross-over experiment, the influence of the antimicrobial agent co-trimoxazole on the single-dose pharmacokinetics of theophylline was studied in six healthy adults by comparing the pharmacokinetic parameters found after intravenous administration of theophylline without and with co-medication of co-trimoxazole for the previous 8 d. Theophylline concentrations in plasma were measured by high-performance liquid chromatography (HPLC) analysis. During each treatment, a concentration-time curve was evaluated. No influence of co-trimoxazole on the rate of elimination and volume of distribution of theophylline could be found, as a result of which theophylline concentrations in plasma were not significantly different in both periods of drug administration. A similar lack of influence of co-trimoxazole may apply to the steady-state pharmacokinetics of theophylline. The present study suggests that both drugs can be given concomitantly without the need for dosage adjustment of theophylline.
在一项开放性交叉试验中，通过比较在未使用复方新诺明以及在之前8天联用复方新诺明的情况下静脉注射茶碱后所发现的药代动力学参数，研究了抗菌药物复方新诺明对6名健康成年人茶碱单剂量药代动力学的影响。通过高效液相色谱（HPLC）分析测定血浆中的茶碱浓度。在每次治疗期间，评估浓度-时间曲线。未发现复方新诺明对茶碱的消除速率和分布容积有影响，因此在两个给药期血浆中的茶碱浓度无显著差异。复方新诺明对茶碱稳态药代动力学可能也有类似的无影响情况。本研究表明，两种药物可以同时给药，而无需调整茶碱的剂量。
