Sihn Duho, Kim Sung-Phil
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, 44919 Republic of Korea.
Biomed Eng Lett. 2024 Oct 1;15(1):159-168. doi: 10.1007/s13534-024-00433-9. eCollection 2025 Jan.
Patients suffering from various neurological disorders, including major depressive disorder (MDD), often exhibit abnormal brain connectivity. In particular, patients with MDD show atypical brain oscillations propagation. This study aims to investigate an association between abnormal brain connectivity and atypical oscillatory propagation of electroencephalogram (EEG) signals in patients with a history of MDD. Previous findings of functional hyperconnectivity in beta oscillations (15-25 Hz) lead us to hypothesize that patients would experience abnormal beta oscillation propagation. Using the local phase gradient (LPG) method, we analyze a publicly available EEG dataset recorded during a probabilistic learning task. Our findings indicate that, upon receiving positive feedback during the learning task, patients with a history of MDD show more pronounced propagation directions of beta oscillations observed in the right frontal region compared to healthy controls. This directional pattern may help differentiate patients with a history of MDD from healthy controls. The observed abnormalities in brain oscillation propagation suggest that cognitive deficits in patients with a history of MDD might stem from excessive and negatively biased information transmission between brain regions.
The online version contains supplementary material available at 10.1007/s13534-024-00433-9.
患有各种神经系统疾病（包括重度抑郁症（MDD））的患者通常表现出大脑连接异常。特别是，MDD患者表现出非典型的脑振荡传播。本研究旨在调查有MDD病史的患者大脑连接异常与脑电图（EEG）信号非典型振荡传播之间的关联。先前关于β振荡（15 - 25赫兹）功能超连接的研究结果使我们推测患者会经历异常的β振荡传播。使用局部相位梯度（LPG）方法，我们分析了在概率学习任务期间记录的一个公开可用的EEG数据集。我们的研究结果表明，在学习任务中收到积极反馈时，有MDD病史的患者与健康对照相比，在右侧额叶区域观察到的β振荡传播方向更为明显。这种方向性模式可能有助于将有MDD病史的患者与健康对照区分开来。观察到的脑振荡传播异常表明，有MDD病史的患者的认知缺陷可能源于大脑区域之间过度且负向偏差的信息传递。
在线版本包含可在10.1007/s13534 - 024 - 00433 - 9获取的补充材料。
