Khan ArshadUllah, Albinsaad Loai, Alessa Mohammed, Aldoughan Alghaydaa Fouad, Alsalem Ammar Jaafar, Almukhaimar Noof Khalid, Alghamdi Abdulrahman Ahmed, Alsahlawi Watan Abdulla, Alahmary Batool Abdullah
Oncology and Breast Oncoplastic Surgery, AlAhsa Hospital, Al-Ahsa City, Eastern Province, Saudi Arabia.
Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa City, Eastern Province, Saudi Arabia.
Int J Breast Cancer. 2024 Dec 31;2024:3765406. doi: 10.1155/ijbc/3765406. eCollection 2024.
This study is aimed at evaluating the effectiveness of TachoSil in controlling lymphatic leakage in breast cancer patients undergoing axillary dissection. By examining its ability to reduce postsurgical lymphatic drainage, the study will assess its impact on complications like seroma formation, recovery time, and overall patient outcomes, including quality of life and reduced healthcare costs. Breast cancer patients treated in the Department of Surgical Oncology at King Abdulaziz Medical City were enrolled to receive either TachoSil or undergo drain placement after axillary dissection. Repeated measures multivariate analysis of variance (MANOVA) was used to observe the difference in lymphatic drainage volume over time considering other covariates, such as age, sex, family history, neoadjuvant chemotherapy (NAC), and stage. The TachoSil group showed significantly lower lymphatic drainage volumes at 24 h (106.5 ± 11.3) than the control group (141.7 ± 13.0) ( < 0.001). There were no significant differences in lymphatic drainage volume at 3 days ( = 0.176) and 7 days ( = 0.091). However, at 10 days, the TachoSil group exhibited significantly lower lymphatic drainage volume (19.9 ± 6.1) than the control group (44.5 ± 9.2) ( < 0.001). Repeated measures MANOVA showed a statistically significant difference in lymphatic drainage over time, with a moderate effect ( < 0.001). The findings suggest that TachoSil sealant effectively reduces early postoperative lymphatic drainage volume and maintains lower drainage rates up to 10 days following axillary dissection in breast cancer patients. The use of TachoSil sealant may have potential benefits in reducing the incidence of complications associated with lymphatic drainage and improving patient outcomes.
本研究旨在评估速即纱（TachoSil）在控制接受腋窝清扫术的乳腺癌患者淋巴漏方面的有效性。通过检查其减少术后淋巴引流的能力，该研究将评估其对诸如血清肿形成、恢复时间以及包括生活质量和降低医疗成本在内的患者总体结局等并发症的影响。在阿卜杜勒阿齐兹国王医疗城外科肿瘤学部接受治疗的乳腺癌患者被纳入研究，在腋窝清扫术后接受速即纱治疗或进行引流管放置。采用重复测量多变量方差分析（MANOVA）来观察考虑其他协变量（如年龄、性别、家族史、新辅助化疗（NAC）和分期）时淋巴引流量随时间的差异。速即纱组在24小时时的淋巴引流量（106.5±11.3）显著低于对照组（141.7±13.0）（<0.001）。在3天（P = 0.176）和7天（P = 0.091）时，淋巴引流量无显著差异。然而，在10天时，速即纱组的淋巴引流量（19.9±6.1）显著低于对照组（44.5±9.2）（<0.001）。重复测量MANOVA显示，淋巴引流随时间存在统计学显著差异，具有中等效应（<0.001）。研究结果表明，速即纱密封剂可有效降低乳腺癌患者腋窝清扫术后早期的淋巴引流量，并在长达10天内维持较低的引流率。使用速即纱密封剂可能在降低与淋巴引流相关的并发症发生率和改善患者结局方面具有潜在益处。
