M Imanbayev Nauryzbay, K Koyshybaev Arip, M Kereyeva Nurgul, A Aitmagambetova Marzhan, B Zharylgapov Azamat
Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Med J Islam Repub Iran. 2024 Sep 18;38:108. doi: 10.47176/mjiri.38.108. eCollection 2024.
The narrative review aims to explore CRC pathogenesis by deciphering genetic-environmental interactions, analyzing the tumor microenvironment's role, and assessing treatment responses. These objectives seek to enhance clinical decision-making and improve CRC patient care through a comprehensive understanding of the disease.
A narrative review from 2019 to 2024 on colorectal cancer (CRC) pathogenesis and treatment strategies was conducted. Systematic literature searches were performed on PubMed, using CRC-related keywords ("Colorectal Neoplasms"[Mesh]) AND "Tumor Microenvironment"[Mesh]. Screening yielded 233 eligible studies, with 14 highly relevant ones included. PRISMA guidelines were followed for transparency and reproducibility.
This narrative review spanning 2019-2024 shows diverse study designs (5 clinical studies, 4 randomized controlled trials, 2 cohort studies, and 3 systematic literature reviews) with varied sample sizes (from 14 to 4000 participants). Genetic mutations like KRAS and BRAF are significant in colorectal cancer pathogenesis, with 8% exhibiting MMR proficiency. Immune cells and paracrine signaling are influential, and therapeutic responses vary, with limited efficacy reported in certain combinations.
This narrative review highlights CRC's multifactorial nature and complex tumor dynamics. Integrating genetic, environmental, and immune factors, personalized therapies are pivotal for efficacy. Continued research is crucial for optimizing treatments and improving patient outcomes, emphasizing the need for multifaceted, patient-tailored approaches in CRC management.
本叙述性综述旨在通过解读基因 - 环境相互作用、分析肿瘤微环境的作用以及评估治疗反应来探索结直肠癌的发病机制。这些目标旨在通过对该疾病的全面了解来加强临床决策并改善结直肠癌患者的护理。
对2019年至2024年关于结直肠癌（CRC）发病机制和治疗策略进行了叙述性综述。在PubMed上进行了系统的文献检索，使用与CRC相关的关键词（“结直肠肿瘤”[医学主题词]）和“肿瘤微环境”[医学主题词]。筛选出233项符合条件的研究，其中纳入了14项高度相关的研究。遵循PRISMA指南以确保透明度和可重复性。
这项涵盖2019 - 2024年的叙述性综述显示了多样的研究设计（5项临床研究、4项随机对照试验、2项队列研究和3项系统文献综述）以及不同的样本量（从14名到4000名参与者）。KRAS和BRAF等基因突变在结直肠癌发病机制中具有重要意义，8% 的患者表现出错配修复功能正常。免疫细胞和旁分泌信号具有影响，治疗反应各不相同，某些联合治疗的疗效有限。
本叙述性综述强调了结直肠癌的多因素性质和复杂的肿瘤动态。整合基因、环境和免疫因素，个性化治疗对于疗效至关重要。持续研究对于优化治疗和改善患者预后至关重要，强调在结直肠癌管理中需要多方面、针对患者的方法
