Zheng Haoning, Yu Cuisong, Yang Lu, Zhou Fenghua, Liu Aijun
Clinical Pathology Department, Shandong Second Medical University, Shandong Province, Weifang, Shandong 261042, P.R. China.
Department of Pathology, The seventh Medical Center, Chinese PLA General Hospital, Beijing, 100700, P.R. China.
J Cancer. 2025 Jan 1;16(3):812-820. doi: 10.7150/jca.104214. eCollection 2025.
Endometrial carcinoma (EC) is the most common malignancies of the female reproductive system in developed countries and areas. Ultrasound-guided and hysteroscopic samplings are commonly used to diagnose EC. However, clinicians question their diagnostic efficacy and the associated patient discomfort. DNA methylation is the widely studied epigenetic alteration in human tumors, and tumor screening and diagnosis. This review summarized common methods for collecting clinical samples for methylation testing. Furthermore, we analyzed the diagnostic evaluation indices of different methylation marker assays in clinical diagnosis and discussed the challenges of methylation testing in the future application of EC diagnosis.
子宫内膜癌（EC）是发达国家和地区女性生殖系统最常见的恶性肿瘤。超声引导下取样和宫腔镜取样常用于诊断EC。然而，临床医生对其诊断效能及相关的患者不适感存在质疑。DNA甲基化是人类肿瘤及肿瘤筛查与诊断中广泛研究的表观遗传改变。本综述总结了用于甲基化检测的临床样本采集常用方法。此外，我们分析了不同甲基化标志物检测在临床诊断中的诊断评估指标，并讨论了甲基化检测在EC诊断未来应用中的挑战。
