Lazim Md Rizman Md Lazin Md, Chellappan Kalaivani, Ugusman Azizah, Isa W Yus Haniff W, Mohamad Mohd Shawal Faizal, Ahmad Wan Amir Nizam Wan, Aminuddin Amilia
Department of Physiology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu, Kelantan, MALAYSIA.
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, MALAYSIA.
Int J Med Sci. 2025 Jan 1;22(2):309-317. doi: 10.7150/ijms.103341. eCollection 2025.
The finger photoplethysmography fitness index (PPGF), a marker of peripheral vascular function, has been linked to heart rate (HR) variability. However, the influence of acute HR changes on resting PPGF, a purported indicator of local blood flow, remains unclear. This study aimed to determine the influence of acute HR changes on resting PPGF. A total of 22 pacemaker recipients (mean age: 52.27 ± 10.43 years) underwent a controlled study. Baseline assessments included demographics, blood pressure (BP), blood analysis, PPGF, and vascular functions. HR was progressively increased from 70 bpm to 90 bpm in 10 bpm increments with 20 min resting periods at baseline and between pacing intervals. HR, PPGF, and BP were recorded at each pacing level. Systolic and diastolic BP increased with rising HR. Conversely, PPGF remained stable across different HR levels (70 bpm: 51.02 ± 11.52%, 80 bpm: 51.15 ± 11.82%, 90 bpm: 49.73 ± 11.55%; p > 0.05), suggesting that resting PPGF is independent of acute HR fluctuations. Our findings demonstrate that PPGF accurately reflects local blood flow, unaffected by short-term HR variations. This study supports the use of PPGF as a reliable marker for vascular health and age assessment, even in individuals with fluctuating HR, such as older adults with multiple comorbidities. Further research is warranted to establish the applicability of PPGF in younger, healthier populations.
手指光电容积脉搏波描记法健康指数（PPGF）是外周血管功能的一个标志物，与心率（HR）变异性有关。然而，急性心率变化对静息PPGF（一种据称的局部血流指标）的影响仍不清楚。本研究旨在确定急性心率变化对静息PPGF的影响。共有22名起搏器植入者（平均年龄：52.27±10.43岁）接受了一项对照研究。基线评估包括人口统计学、血压（BP）、血液分析、PPGF和血管功能。心率从70次/分钟逐步增加到90次/分钟，每次增加10次/分钟，在基线时以及起搏间隔之间有20分钟的休息期。在每个起搏水平记录心率、PPGF和血压。收缩压和舒张压随心率升高而升高。相反，PPGF在不同心率水平下保持稳定（70次/分钟：51.02±11.52%，80次/分钟：51.15±11.82%，90次/分钟：49.73±11.55%；p>0.05），这表明静息PPGF独立于急性心率波动。我们的研究结果表明，PPGF准确反映局部血流，不受短期心率变化的影响。本研究支持将PPGF用作血管健康和年龄评估的可靠标志物，即使在心率波动的个体中，如患有多种合并症的老年人。有必要进行进一步研究以确定PPGF在更年轻、更健康人群中的适用性。
