Babakr Abdullatif Taha, Nour Eldein Mohamed Mahmoud
Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Explor Target Antitumor Ther. 2025 Jan 2;6:1002284. doi: 10.37349/etat.2025.1002284. eCollection 2025.
Breast cancer (BC), a disease in which abnormal breast cells grow out of control and form tumors, is a prevalent life-threatening disease worldwide. Oxidative stress has been implicated in the development and progression of various cancers, including BC. Assessing lipid peroxidation and overall antioxidant status in BC offers valuable information on disease progression, patient prognosis, and the effectiveness of therapeutic options.
A total of 150 women were categorized into three groups: normal, benign mass, and BC. Participants were selected and evaluated at the cancer clinic; fasting blood samples were collected, and total antioxidant capacity (TAC), oxidized low-density lipoprotein (Ox-LDL), cancer antigen (CA) 15-3, and carcinoembryonic antigen (CEA) were measured. Subsequently, statistical analysis was performed to compare the levels of these parameters in different groups and examine the analytical performance of TAC and Ox-LDL in BC.
In patients with malignancy, the serum level of TAC was significantly decreased compared with the benign group (8.3 U/mL and 16.04 U/mL, respectively) ( < 0.001). Healthy controls exhibited higher levels of TAC (43.4 U/mL). The levels of Ox-LDL in BC were significantly increased in both malignant and benign groups (3,831 pg/mL and 1,234 pg/mL, respectively) compared with normal controls (682 pg/mL) ( < 0.001). CEA and CA15-3 were drastically increased in the BC groups compared with the control group. A significant area under the curve was observed in the receiver operating characteristic (ROC) curve analysis for TAC (0.975, < 0.001) and Ox-LDL (0.986, < 0.001).
This study revealed that patients with BC had lower TAC and higher Ox-LDL serum levels, indicating elevated oxidative stress. These levels may serve as promising monitoring parameters in BC.
乳腺癌（BC）是一种异常乳腺细胞失控生长并形成肿瘤的疾病，是全球一种普遍存在的危及生命的疾病。氧化应激与包括乳腺癌在内的各种癌症的发生和发展有关。评估乳腺癌中的脂质过氧化和总体抗氧化状态可为疾病进展、患者预后及治疗方案的有效性提供有价值的信息。
总共150名女性被分为三组：正常组、良性肿块组和乳腺癌组。参与者在癌症诊所被挑选并进行评估；采集空腹血样，测量总抗氧化能力（TAC）、氧化型低密度脂蛋白（Ox-LDL）、癌抗原（CA）15-3和癌胚抗原（CEA）。随后，进行统计分析以比较不同组中这些参数的水平，并检验TAC和Ox-LDL在乳腺癌中的分析性能。
在恶性肿瘤患者中，TAC的血清水平与良性组相比显著降低（分别为8.3 U/mL和16.04 U/mL）（<0.001）。健康对照组的TAC水平更高（43.4 U/mL）。与正常对照组（682 pg/mL）相比，恶性组和良性组中乳腺癌患者的Ox-LDL水平均显著升高（分别为3,831 pg/mL和1,234 pg/mL）（<0.001）。与对照组相比，乳腺癌组中的CEA和CA15-3大幅升高。在总抗氧化能力（TAC）（0.975，<0.001）和氧化型低密度脂蛋白（Ox-LDL）（0.986，<0.001）的受试者工作特征（ROC）曲线分析中观察到显著的曲线下面积。
本研究表明，乳腺癌患者的TAC较低，血清Ox-LDL水平较高，表明氧化应激升高。这些水平可能是乳腺癌中有前景的监测参数。
