Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Saudi Arabia.
Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Saudi Arabia.
Exp Gerontol. 2021 Jul 15;150:111359. doi: 10.1016/j.exger.2021.111359. Epub 2021 Apr 24.
Beta 2 microglobulin (Β2M) is expressed in all nucleated cells, it interplays with mediators to regulate and modulate cellular functions. Its role in aging associated disorders has been documented recently. Oxidative stress has been known to play a direct implication on these disorders. Therefore, there is a rationality to explore the function of Β2M in oxidative stress in elderly people. The aim of the study was to assess the Β2M levels in different group of age, and to study the correlation between Β2M and oxidative stress. Actually, the serum levels of Β2M increased significantly in old people comparing to youngers. In addition, there was a positive correlation between Β2M levels and the age of participants (p < 0.001). In addition, there was a positive correlation between Β2M levels and Malondialdehyde (MDA) (p < 0.001), which underscored the possible role of Β2M in oxidative stress. To confirm the previous result, the correlation between total antioxidant capacity (TAC) and Β2M was assessed. There was a negative correlation between them (p < 0.001). These results suggested a possible role of Β2M in oxidative stress status in elderly people; in addition, it suggested the ability of using Β2M as a novel biomarker for oxidative stress. However, further work should be conducted to explore the exact role of Β2M in oxidative stress, and to include large sample size to confirm the results before translating the findings to clinic.
β2 微球蛋白（β2M）在所有有核细胞中表达，它与介质相互作用以调节和调节细胞功能。最近已经记录了其在与衰老相关的疾病中的作用。氧化应激已被证明对这些疾病有直接影响。因此，有理由探索β2M 在老年人氧化应激中的作用。本研究的目的是评估不同年龄组的β2M 水平，并研究β2M 与氧化应激之间的相关性。实际上，β2M 的血清水平在老年人中与年轻人相比显著增加。此外，β2M 水平与参与者的年龄之间呈正相关（p<0.001）。此外，β2M 水平与丙二醛（MDA）之间存在正相关（p<0.001），这突显了β2M 在氧化应激中的可能作用。为了证实先前的结果，评估了总抗氧化能力（TAC）与β2M 之间的相关性。它们之间呈负相关（p<0.001）。这些结果表明β2M 在老年人氧化应激状态中可能发挥作用；此外，它表明β2M 可作为氧化应激的新型生物标志物的能力。然而，应该进行进一步的工作来探索β2M 在氧化应激中的确切作用，并包括更大的样本量来确认结果，然后再将研究结果转化为临床。
