Pocuca Nina, Campbell Gabrielle, Ellem Rhiannon, Newland Grace, Walter Zoe, Dignan Julie, Stokes Holly, Hides Leanne
National Centre for Youth Substance Use Research (NCYSUR), School of Psychology, The University of Queensland, Brisbane, Australia.
Lives Lived Well, Brisbane, Australia.
Subst Use Misuse. 2025;60(5):775-785. doi: 10.1080/10826084.2024.2447437. Epub 2025 Jan 9.
Polysubstance use is common among people who use methamphetamine. This prospective study examined the three-month polysubstance use profiles among people enrolled in outpatient treatment for methamphetamine use and associated substance use, mental health, and treatment correlates.
The present study used routinely collected client-reported outcome measures data from = 1,507 clients enrolled in outpatient treatment who reported methamphetamine as their primary drug of concern ( = 34.48; SD = 8.68; 56% male). Past-month substance use was assessed at baseline, one-, and three-months.
Repeated measures latent class analyses revealed four classes: (1) high and decreasing methamphetamine + stable moderate alcohol + stable high cannabis and daily tobacco ( = 474, 31.45%); (2) stable high methamphetamine + stable high alcohol and daily tobacco ( = 346, 22.96%); (3) low and decreasing methamphetamine + stable moderate daily tobacco ( = 322, 21.37%); (4) stable high methamphetamine + stable moderate daily tobacco ( = 365, 24.22%). Probability of using substances other than methamphetamine remained relatively stable for each class across time. Classes 1 and 4 had greatest severity of methamphetamine involvement at baseline and three-months. Class 1 had greater odds of experiencing moderate-to-severe depression and anxiety, and PTSD and psychosis, compared to class 3.
Individuals enrolled in outpatient treatment who report methamphetamine as their primary drug of concern report distinct substance use patterns, although daily tobacco use was mostly ubiquitous. Polysubstance use was widespread, with 79% of participants having moderate-to-high probability of polysubstance use at all timepoints. Clients with the most severe polysubstance use had the highest rates of co-occurring psychopathology.
多物质使用在使用甲基苯丙胺的人群中很常见。这项前瞻性研究调查了参加甲基苯丙胺使用及相关物质使用、心理健康和治疗相关性门诊治疗的人群三个月内的多物质使用情况。
本研究使用了常规收集的客户报告结局测量数据，这些数据来自1507名参加门诊治疗的客户，他们报告甲基苯丙胺是他们主要关注的药物（平均年龄 = 34.48岁；标准差 = 8.68；56%为男性）。在基线、1个月和3个月时评估过去一个月的物质使用情况。
重复测量潜在类别分析揭示了四类：（1）高且逐渐减少的甲基苯丙胺使用 + 稳定的中度酒精使用 + 稳定的高剂量大麻和每日烟草使用（n = 474，31.45%）；（2）稳定的高剂量甲基苯丙胺使用 + 稳定的高剂量酒精和每日烟草使用（n = 346，22.96%）；（3）低且逐渐减少的甲基苯丙胺使用 + 稳定的中度每日烟草使用（n = 322，21.37%）；（4）稳定的高剂量甲基苯丙胺使用 + 稳定的中度每日烟草使用（n = 365，24.22%）。各类别使用除甲基苯丙胺以外物质的概率在不同时间相对稳定。第1类和第4类在基线和3个月时甲基苯丙胺使用的严重程度最高。与第3类相比，第1类经历中度至重度抑郁、焦虑、创伤后应激障碍和精神病的几率更高。
将甲基苯丙胺作为主要关注药物的门诊治疗患者报告了不同的物质使用模式，尽管每日烟草使用大多普遍存在。多物质使用很普遍，79%的参与者在所有时间点都有中度至高概率的多物质使用。多物质使用最严重的患者共病精神病理学的发生率最高。
