Willis Don E, Narcisse Marie-Rachelle, James Laura, Selig James P, Ason Mohammed, Scott Aaron J, Cornett Lawrence E, McElfish Pearl A
College of Medicine, University of Arkansas for Medical Sciences Northwest, Springdale, Arkansas, USA.
Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA.
Clin Transl Sci. 2025 Jan;18(1):e70042. doi: 10.1111/cts.70042.
Vaccine hesitancy is an attitude of indecision toward vaccination that is related to but not determinative of vaccination behaviors. Although theories of vaccine hesitancy emphasize it is often vaccine-specific, we do not know the extent to which this is true across sociodemographic groups. In this study, we asked: What latent classes of vaccine hesitancy might exist when examining parents' attitudes toward vaccines in general and COVID-19 and human papillomavirus (HPV) vaccination specifically? Which sociodemographic, health access, and health-related variables are predictive of membership in those classes? To answer those questions, we analyze online survey data from parents of pediatric patients recruited through eight clinics within the University of Arkansas for Medical Sciences Rural Research Network. Data were collected between September 16, 2022 and December 6, 2022. Latent class analysis revealed three underlying classes of vaccine hesitancy, or hesitancies: The "Selectively Hesitant," the "COVID-Centric Hesitant," and the "Pervasively Hesitant." Significant predictors of class membership were age, education, health insurance status, and usual source of care. Vaccine hesitancy may be specific to certain vaccines for some parents and more generalized for others. The distinct classes of vaccine hesitancy revealed in this study suggest the need for distinct approaches to addressing vaccine hesitancy depending on the population.
疫苗犹豫是一种对疫苗接种犹豫不决的态度，它与疫苗接种行为相关，但并非决定因素。尽管疫苗犹豫理论强调它通常是针对特定疫苗的，但我们并不清楚在不同社会人口群体中这种情况的真实程度。在本研究中，我们提出了以下问题：在考察父母对一般疫苗以及特定的新冠病毒疫苗和人乳头瘤病毒（HPV）疫苗的态度时，可能存在哪些潜在的疫苗犹豫类别？哪些社会人口学、医疗服务可及性和健康相关变量能够预测这些类别的归属？为了回答这些问题，我们分析了通过阿肯色大学医学科学农村研究网络内的八家诊所招募的儿科患者父母的在线调查数据。数据收集于2022年9月16日至2022年12月6日之间。潜在类别分析揭示了三种潜在的疫苗犹豫类别，即：“选择性犹豫”、“以新冠为中心的犹豫”和“普遍犹豫”。类别的显著预测因素包括年龄、教育程度、健康保险状况和通常的医疗服务来源。疫苗犹豫对一些父母来说可能是特定于某些疫苗的，而对另一些父母来说则更为普遍。本研究中揭示的不同疫苗犹豫类别表明，需要根据人群采取不同的方法来解决疫苗犹豫问题。
