Pei Yi, Li Shenglong
Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province, China.
The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, Shenyang, Liaoning, China.
Int J Surg. 2025 Feb 1;111(2):2112-2130. doi: 10.1097/JS9.0000000000002195.
Osteosarcoma (OS) is a prevalent primary malignant bone tumor, typically managed through a combination of neoadjuvant chemotherapy and surgical interventions. Recent advancements in early detection and the use of novel chemotherapeutic agents have significantly improved the 5-year survival rate of OS patients. However, some patients fail to achieve the desired treatment outcomes despite undergoing intensive chemotherapy and surgical procedures, with chemotherapy resistance emerging as a critical factor contributing to therapeutic failure in OS. Noncoding RNAs (ncRNAs) are a group of RNAs that lack protein-coding capacity but play a crucial role in tumor progression by modulating various biological characteristics of cancer cells, such as proliferation, apoptosis, migration, invasion, and drug resistance. Emerging evidence indicates that the dysregulated expression of numerous ncRNAs in OS cells can influence the response to chemotherapeutic agents by modulating processes such as cell apoptosis, signaling pathways, intracellular drug concentrations, and cell autophagy. This review aims to elucidate the roles and mechanisms of ncRNAs in mediating drug resistance in OS, offering new insights for investigating novel pathways underlying drug resistance, overcoming tumor resistance to therapeutics, and developing innovative chemotherapeutic strategies.
骨肉瘤（OS）是一种常见的原发性恶性骨肿瘤，通常通过新辅助化疗和手术干预相结合的方式进行治疗。早期检测和新型化疗药物使用方面的最新进展显著提高了骨肉瘤患者的5年生存率。然而，一些患者尽管接受了强化化疗和手术治疗，仍未能达到预期的治疗效果，化疗耐药性成为导致骨肉瘤治疗失败的关键因素。非编码RNA（ncRNAs）是一类缺乏蛋白质编码能力的RNA，但通过调节癌细胞的各种生物学特性，如增殖、凋亡、迁移、侵袭和耐药性，在肿瘤进展中发挥关键作用。新出现的证据表明，骨肉瘤细胞中众多ncRNAs的表达失调可通过调节细胞凋亡、信号通路、细胞内药物浓度和细胞自噬等过程影响对化疗药物的反应。本综述旨在阐明ncRNAs在介导骨肉瘤耐药性中的作用和机制，为研究耐药性的新途径、克服肿瘤对治疗的耐药性以及制定创新的化疗策略提供新的见解。
