Issenman R M, Slack R, MacDonald L, Taylor W
Can Med Assoc J. 1985 Apr 1;132(7):781-4.
A suburban Ontario community hospital encountered 21 +/- 1 overdoses of children's multiple vitamins yearly between 1978 and 1981. Of these, 35% involved one particular cartoon character preparation. Parents were surveyed to determine whether this particular preparation resulted in a disproportionate number of accidental overdoses. However, the use of vitamins with a cartoon character format did not lead to a greater risk of overdose than did conventional preparations. Of the 1051 families who had given multiple vitamins to their children 34 (3%) had experienced an overdose. The number of vitamin preparations used by each family was the most powerful determinant of overdose (p less than 0.001). The risk of accidental overdose increased from 1.5% with one multiple-vitamin preparation to 8% with four or more preparations. Among all the variables examined, exposure was the most important element in the risk of multiple-vitamin overdose.
1978年至1981年间，安大略省一个郊区社区医院每年都会接诊21±1例儿童多种维生素过量病例。其中，35%涉及一种特定的卡通形象制剂。对家长进行了调查，以确定这种特定制剂是否导致意外过量服用的比例过高。然而，与传统制剂相比，使用带有卡通形象的维生素制剂并不会导致更高的过量服用风险。在1051个给孩子服用多种维生素的家庭中，有34个（3%）曾发生过过量服用。每个家庭使用的维生素制剂数量是过量服用的最有力决定因素（p<0.001）。意外过量服用的风险从使用一种多种维生素制剂时的1.5%增加到使用四种或更多制剂时的8%。在所有检查的变量中，接触是多种维生素过量风险中最重要的因素。
