Seo I S, Clark S A, McGovern F D, Clark D L, Johnson E H
Cancer. 1985 Apr 1;55(7):1597-603. doi: 10.1002/1097-0142(19850401)55:7<1597::aid-cncr2820550731>3.0.co;2-0.
A leiomyosarcoma of the urinary bladder occurred in a 17-year-old boy who was treated with a total dose of 67 g cyclophosphamide over a period of 5 years for Hodgkin's disease diagnosed at the age of 4. Cyclophosphamide was discontinued at the age of 9 because of gross hematuria, and intermittent hematuria recurred 8 years after (at the age of 17) the cessation of this drug. A large exophytic tumor found in the urinary bladder was diagnosed as leiomyosarcoma by light and electron microscopic studies. In addition, there were microscopic features of long-term cyclophosphamide toxicity throughout the bladder wall.
一名17岁男孩患膀胱平滑肌肉瘤，该男孩4岁时被诊断为霍奇金病，在5年时间里共接受了67克环磷酰胺治疗。9岁时因肉眼血尿停用环磷酰胺，停药8年后（17岁时）间歇性血尿复发。膀胱内发现的一个大的外生性肿瘤经光镜和电镜检查诊断为平滑肌肉瘤。此外，整个膀胱壁都有长期环磷酰胺毒性的微观特征。
