Shah S A
Cancer Lett. 1985 Mar;26(2):235-40. doi: 10.1016/0304-3835(85)90031-x.
Corynebacterium parvum was investigated in the response of rat Mc7 sarcoma to local waterbath hyperthermia. Heat treatment of 1-1.5 cm3 foot tumors at 43 degrees C for 2 h resulted in complete regression of 71% of the tumors. The Mc7 cure was reduced to 31% when the tumors were heated at 43 degrees C for 1.5 h. C. parvum (700 micrograms, i.v.) when given 1-3 days before tumor heating at 43 degrees C for 1.5 h increased the host phagocytic activity, and the tumor regression from 31% to 65% (P less than 0.05). C. parvum by itself had no curative effect on the tumor, and it did not enhance the thermal response of normal rat foot to hyperthermia. These findings suggest that host response to tumor heating may be 'non-specific' in nature involving phagocytes of the reticulo-endothelial system.
研究了微小棒状杆菌对大鼠Mc7肉瘤局部水浴热疗反应的影响。对体积为1 - 1.5立方厘米的足部肿瘤在43℃进行2小时的热处理，结果71%的肿瘤完全消退。当肿瘤在43℃加热1.5小时时，Mc7肿瘤的治愈率降至31%。在43℃对肿瘤进行1.5小时加热前1 - 3天静脉注射微小棒状杆菌（700微克），可增强宿主吞噬活性，使肿瘤消退率从31%提高到65%（P < 0.05）。微小棒状杆菌本身对肿瘤无治疗作用，也不增强正常大鼠足部对热疗的反应。这些发现表明，宿主对肿瘤加热的反应本质上可能是“非特异性的”，涉及网状内皮系统的吞噬细胞。
