Urano M, Suit H D, Dunn P, Lansdale T, Sedlacek R S
Cancer Res. 1979 Sep;39(9):3454-7.
The effect of Corynecbacterium parvum treatment on the thermal response of animal tumors was studied. Tumors were methylcholanthrene-induced (FSa-II) and spontaneous (FSa-I) fibrosarcomas in C3Hf/Sed mice. C. parvum was given i.v. and was followed by local hyperthermia at 43.5 degrees 3 days later. Cell survival determined by lung colony assays showed that preadministration of C. parvum insignificantly enhanced the thermal response of both tumors. Studies of delay of tumor growth for FSa-II demonstrated that the enhancement ratio decreased with increasing time of treatment and reached a minimum of approximately equal to 1.7. The enhancement ratio for the time at hyperthermia which achieved tumor control in one-half of the treated tumors was 1.7. Together with our previous results on normal tissue responses, the therapeutic gain factor for obtaining 50% tumor control was found to be 1.1 (1.7/1.55) for the weekly immunogenic FSa-II tumor, while it was 2.3 for moderately immunogenic FSa-I as reported previously.
研究了短小棒状杆菌治疗对动物肿瘤热反应的影响。肿瘤为C3Hf/Sed小鼠中由甲基胆蒽诱导的（FSa-II）和自发的（FSa-I）纤维肉瘤。静脉注射短小棒状杆菌，3天后对局部进行43.5摄氏度的热疗。通过肺集落测定法确定的细胞存活率表明，预先给予短小棒状杆菌对两种肿瘤的热反应增强作用不显著。对FSa-II肿瘤生长延迟的研究表明，增强率随治疗时间的增加而降低，最低达到约等于1.7。在热疗时，使一半治疗肿瘤达到肿瘤控制的时间点的增强率为1.7。结合我们之前关于正常组织反应的结果，发现对于每周具有免疫原性的FSa-II肿瘤，获得50%肿瘤控制的治疗增益因子为1.1（1.7/1.55），而如先前报道的，对于中等免疫原性的FSa-I肿瘤，该因子为2.3。
