Vaheb Saeed, Yazdan Panah Mohammad, Mohammadi Mohammad, Sadri Mohammad Amin, Ebrahimi Narges, Loghmani Sarina, Beigi Marjan, Shaygannejad Vahid, Mirmosayyeb Omid
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, 81839-83434 Isfahan, Iran.
Student Research Committee, Shahrekord University of Medical Sciences, 88157-13471 Shahrekord, Iran.
J Sex Med. 2025 Jan 9;22(2):274-281. doi: 10.1093/jsxmed/qdae188.
Sexual dysfunction (SF) is a prevalent and distressing comorbidity in males with multiple sclerosis (MwMS) and neuromyelitis optica spectrum disorder (MwNMOSD).
This study aimed to assess the SF in MwMS and MwNMOSD in comparison to male healthy controls (HCs) and identify its associated predictors.
This case-control study was conducted from February 2023 to January 2024 at the MS clinic of Kashani Hospital, Isfahan, Iran. Participants included 49 MwMS, 27 MwNMOSD, and 40 HCs. Demographic, clinical, and psychological data were collected, and SF was evaluated by the International Index of Erectile Function (IIEF). Linear regression was used to assess relationships between variables.
SF was significantly worse in the MwMS and MwNMOSD compared to the HCs.
SF was significantly lower in MwMS and MwNMOSD compared to HCs. In MwMS, significant independent predictors of SF included partner's education (B = -2.7, P = .003), anxiety (B = -0.6, P = .003), and depression (B = -0.3, P = .026). In MwNMOSD, significant independent predictors of SF were EDSS (B = -5.7, P = .007) and anxiety (B = -1, P = .002).
Controlling risk factors such as depression and anxiety can improve SF of MwMS to a significant extent.
Despite limitations like the cross-sectional design and exclusion of certain variables, our study identifies significant associations between sexual dysfunction and various risk factors in MwMS and MwNMOSD, emphasizing the need for future longitudinal research.
MwMS and MwNMOSD exhibited worse SF than HCs. Multiple factors have been identified as independent predictors of SF within these patient groups.
性功能障碍（SF）在患有多发性硬化症的男性（MwMS）和视神经脊髓炎谱系障碍的男性（MwNMOSD）中是一种普遍且令人苦恼的合并症。
本研究旨在评估MwMS和MwNMOSD中的性功能障碍，并与男性健康对照者（HCs）进行比较，同时确定其相关的预测因素。
本病例对照研究于2023年2月至2024年1月在伊朗伊斯法罕卡沙尼医院的多发性硬化症诊所进行。参与者包括49名MwMS患者、27名MwNMOSD患者和40名健康对照者。收集了人口统计学、临床和心理数据，并通过国际勃起功能指数（IIEF）评估性功能障碍。采用线性回归分析变量之间的关系。
与健康对照者相比，MwMS和MwNMOSD患者的性功能障碍明显更严重。
与健康对照者相比，MwMS和MwNMOSD患者的性功能障碍明显更低。在MwMS患者中，性功能障碍的显著独立预测因素包括伴侣的教育程度（B = -2.7，P = 0.003）、焦虑（B = -0.6，P = 0.003）和抑郁（B = -0.3，P = 0.026）。在MwNMOSD患者中，性功能障碍的显著独立预测因素是扩展残疾状态量表（EDSS）（B = -5.7，P = 0.007）和焦虑（B = -1，P = 0.002）。
控制抑郁和焦虑等风险因素可在很大程度上改善MwMS患者的性功能障碍。
尽管存在横断面设计和排除某些变量等局限性，但我们的研究确定了性功能障碍与MwMS和MwNMOSD中各种风险因素之间的显著关联，强调了未来进行纵向研究的必要性。
MwMS和MwNMOSD患者的性功能障碍比健康对照者更严重。在这些患者群体中，已确定多种因素是性功能障碍的独立预测因素。
