Nordlund J J, Kirkwood J, Forget B M, Scheibner A, Albert D M, Lerner E, Milton G W
Cancer Res. 1985 Apr;45(4):1855-61.
We examined 296 patients with a history of melanoma and 145 controls for the presence of atypical (dysplastic) nevi. We found that 34% of patients with melanoma and 7% of controls had clinically atypical (dysplastic) nevi. Patients and controls with atypical (dysplastic) nevi had more nevi than the subjects without. The number of nevi varies negatively and significantly with age (r = 0.37, P less than 0.001). Ten % of patients and controls had hypopigmented halos around one or more nevi. Both patients and comparison subjects with atypical (dysplastic) nevi tended to have this subtle variant of halo nevi more often than those without (r = 0.17, P less than 0.01). The number of nevi on the irides of melanoma patients was greater than that in the comparison group. The results of this study suggest that patients with a melanoma exhibit more commonly cutaneous and ocular pigmentary lesions than comparison subjects without a melanoma.
我们检查了296例有黑素瘤病史的患者和145名对照者，以确定是否存在非典型（发育异常）痣。我们发现，34%的黑素瘤患者和7%的对照者有临床非典型（发育异常）痣。有非典型（发育异常）痣的患者和对照者比没有的受试者有更多的痣。痣的数量与年龄呈显著负相关（r = 0.37，P小于0.001）。10%的患者和对照者在一个或多个痣周围有色素减退晕。有非典型（发育异常）痣的患者和对照受试者比没有的人更常出现这种细微变异的晕痣（r = 0.17，P小于0.01）。黑素瘤患者虹膜上的痣数量多于对照组。本研究结果表明，与没有黑素瘤的对照受试者相比，黑素瘤患者更常出现皮肤和眼部色素沉着病变。
