Haase Ozan, Barkawi Arabella, Mrowka Petra, Krengel Sven
Hautpartner Lübeck, Lindenplatz 6, 23554, Lübeck, Germany.
Arch Dermatol Res. 2025 Jan 9;317(1):208. doi: 10.1007/s00403-024-03671-0.
Plantar warts, or verrucae plantares, are skin lesions on the soles of the feet caused by human papillomavirus (HPV). These warts are prevalent and affect up to 33% of children and 3.5% of adults. While they may regress spontaneously, plantar warts often persist and resist conventional treatments such as excision, cryotherapy, and laser procedures.This study investigated microwave-induced hyperthermia as a treatment for recalcitrant plantar warts. The study was conducted at a dermatology practice in Lübeck, Germany. Thirty-two adult patients with long-lasting, treatment-resistant plantar warts were randomly assigned to either a treatment or placebo group. The treatment group received microwave therapy (Swift, Emblation Medical Ltd., UK), while the placebo group underwent sham treatment with a ruby laser (Sinon, Alma Lasers Ltd., Israel). Treatments were administered every four weeks, for a total of 3 treatments, with a follow-up period of 3 months after the third session. The primary outcome was complete wart clearance.Of the 32 participants, 6 dropped out, leaving 28 for analysis. Complete clearance was achieved in 27.3% of the treatment group (3/11) compared to 0% of the placebo group (p = 0.032). Six patients in the treatment group achieved a partial response ranging from 41.1 to 88.4% of the total wart area, with a partial clearance rate of 54.5% versus 13.3% in the placebo group. The average pain score for the microwave treatment group was 5.44.Microwave therapy has proven to be superior to placebo treatment. The clearance rate in this study was lower than that reported in previous uncontrolled studies, potentially due to differences in treatment protocols. The pain level and cost of consumables present challenges. However, further studies are needed to optimize the protocol and assess its efficacy in larger populations and for different wart types.
跖疣，即寻常疣，是由人乳头瘤病毒（HPV）引起的脚底皮肤病变。这些疣很常见，高达33%的儿童和3.5%的成年人会受到影响。虽然它们可能会自行消退，但跖疣通常会持续存在，并对切除、冷冻疗法和激光手术等传统治疗产生抵抗。本研究调查了微波诱导热疗作为顽固性跖疣的一种治疗方法。该研究在德国吕贝克的一家皮肤科诊所进行。32名患有长期、治疗抵抗性跖疣的成年患者被随机分配到治疗组或安慰剂组。治疗组接受微波治疗（Swift，英国Emblation Medical Ltd.），而安慰剂组接受红宝石激光假治疗（Sinon，以色列Alma Lasers Ltd.）。每四周进行一次治疗，共进行3次治疗，第三次治疗后随访3个月。主要结果是疣体完全清除。32名参与者中，6人退出，剩下28人进行分析。治疗组27.3%（3/11）的患者实现了完全清除，而安慰剂组为0%（p = 0.032）。治疗组有6名患者实现了部分缓解，范围为总疣体面积的41.1%至88.4%，部分清除率为54.5%，而安慰剂组为13.3%。微波治疗组的平均疼痛评分为5.44。事实证明，微波治疗优于安慰剂治疗。本研究中的清除率低于先前非对照研究报告的清除率，这可能是由于治疗方案的差异。疼痛程度和耗材成本带来了挑战。然而，需要进一步研究来优化方案，并评估其在更大人群和不同疣类型中的疗效。
